Evolutionary History of Orthopoxvirus Proteins Similar to Human Complement Regulators

Emily Ciulla^a,1,4, Andrea Emery^a,2,4, Dina Konz^a,3,4, and Julia Krushkal^b,*

^aDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA 01609
^bDepartment of Preventive Medicine and Center of Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN 38163

^*Corresponding author

¹Present address: Averion, Inc., Framingham, MA.
²Present address: Harvard Medical School, New England Primate Research Center, Southboro, MA.
³Present address: ViaCell, Inc., Worcester, MA.

⁴E. C., A. E., and D. K. contributed equally to this work.

List of protein sequences analyzed. GenBank accession numbers are provided for each sequence.

Alignment of short consensus repeats used in phylogenetic tree inference. Names of viral SCRs are marked by asterisks (*).

Sequence logos of aligned human and viral short consensus repeats in detailed and condensed view.

Phylogenetic tree inferred from short consensus repeats of VCP, SPICE, IMP, and human complement regulators. The tree was inferred by the neighbor-joining method using amino acid distances with correction for variation of substitution rates among sites. Abbreviations: C4bpa, C4 binding protein, a chain (C4bpa). SPICE_Ind, smallpox inhibitor of complement enzymes (SPICE) from variola major, strain India. SPICE_Bsh, SPICE from variola major, strain Bangladesh. All other abbreviations of human and orthopoxvirus complement regulators are as described in the text. Clusters of repeats similar to viral SCRs 1-4 are shown by brackets. Asterisks (*) indicate viral SCRs.

Published in Gene, Volume 355, 1 August 2005, pages 40-47.


This page last revised: 09/01/2005.