Murray Heimberg, Ph.D., M.D.
Professor of Pharmacology
Professor of Medicine

Room 115 Crowe Research Building
(901) 448-6000
FAX (901) 448-7300
mheimberg@utmem.edu

Education:

Cornell University, Ithaca, NY., B.S, 1948, Bacteriology
Cornell University, Ithaca, NY., M.N.S., 1949, Nutrition
Duke University, Durham, NC., Ph.D., 1952, Biochemistry
Vanderbilt University, Nashville, TN., M.D., 1959, Medicine

Research Interests:

Metabolic regulation and endocrine pharmacology; serum lipids-lipoproteins and atherosclerosis; hepatic function, drug metabolism, and hepatotoxicity; toxicology

Selected Publications:

Regulation of Hepatic secretion of the very low density lipoprotein by dietary cholesterol. T.V. Fungwe, L. Cagen, H.G. Wilcox, and M. Heimberg. J. Lipid Research, 33, 179-191 (1992).

Concentration-dependent effects of eicosapentaenoic and on VLDL secretion by the isolated perfused rat liver. Z.J. Zhang, H.G. Wilcox, L. Castellani, T.V. Fungwe, M.B. Elam, and M. Heimberg. Lipids 28, 419-425 (1993).

Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat. T.V. Fungwe, L.M. Cagen, G.A. Cook, H.G. Wilcox, and M. Heimberg. J. Lipid Res. 34, 933-941 (1993).

Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid. T.V. Fungwe, J. Fox, L.M. Cagen, H.G. Wilcox, and M. Heimberg. J. Lipid Res.35:311-318 (1994).

Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing. F.E. Thorngate, R. Raghow, H.G. Wilcox, C.S. Werner, M. Heimberg, and M.B. Elam. Proc. Natl. Acad. Sci., USA, 91:5392-5396, 1994.

Altered hepatic catabolism of low density lipoprotein subjected to in vitro lipid peroxidation. W.L. Stone, M. Heimberg, R.L. Scott, I. LeClair, and H. G. Wilcox. Biochem J. 297:5734-579 (1994).

Fungwe TV, Fox JE, Cagen LM, Wilcox HG, Heimberg M . Stimulation of fatty acid biosynthesis by dietary cholesterol and of cholesterol synthesis by dietary fatty acid. J Lipid Res 35(2):311-8, 1994

Stone WL, Heimberg M, Scott RL, LeClair I, Wilcox HG . Altered hepatic catabolism of low-density lipoprotein subjected to lipid peroxidation in vitro. Biochem J 297 ( Pt 3):573-9, 1994

Fungwe TV, Cagen LM, Wilcox HG, Heimberg M . Effects of dietary cholesterol on hepatic metabolism of free fatty acid and secretion of VLDL in the hamster. Biochem Biophys Res Commun May 200(3):1505-11, 1994.

Thorngate FE, Raghow R, Wilcox HG, Werner CS, Heimberg M, Elam MB . Insulin promotes the biosynthesis and secretion of apolipoprotein B-48 by altering apolipoprotein B mRNA editing. Proc Natl Acad Sci U S A 91(12):5392-6, 1994.

Hughes TA, Heimberg M, Wang X, Wilcox H, Hughes SM, Tolley EA, Desiderio DM, Dalton JT. Comparative lipoprotein metabolism of myristate, palmitate, and
stearate in normolipidemic men. Metabolism 45(9):1108-18, 1996.

Elam MB, Cushman W, Applegate WB, Heimberg M. Recent developments in coronary heart disease prevention: the and west of Scotland studies. Tenn Med May;90(5):189-9, 1997.

von Wronski MA, Hirano KI, Cagen LM, Wilcox HG, Raghow R, Thorngate FE, Heimberg M, Davidson NO, Elam MB. Insulin increases expression of apobec-1, the catalytic subunit of the apolipoprotein B mRNA editing complex in rat hepatocytes. Metabolism 47(7):869-73, 1998.