Fu-Ming Zhou, Ph.D.

Assistant Professor

Crowe Building Room 315
Phone:  901-448-1779   
Fax:  901-448-7300
fzhou3@utmem.edu

M.D. -- SuZhou Medical College, SuZhou, China, 1985
Ph.D. -- Department of Physiology and Biophysics, University of Alabama, Birmingham, Alabama, 1996
Postdoctoral Training -- Department of Neuroscience, Baylor College Medicine, Houston, Texas

Research Interest:

Dr. Zhou currently conducts a multidisciplinary research program designed to determine the molecular, cellular and neuropharmacological mechanisms of the brain monoamine systems. Particular attention is being paid to the contributions of these monoamine systems to neuropsychiatric disorders such as Parkinson’s disease, depression, schizophrenia, drug abuse, and attention deficit hyperactivity disorder (ADHD). We use rodents as our experimental animals. Mutant mice are used in specific cases.

Several techniques are used in the laboratory:

• Electrophysiology-patch clamp
• Molecular biology (single cell RT-PCR in combination with patch clamp; gene expression profiling and manipulation)
• Electrochemistry (fast cyclic voltammetry at the carbon fiber microelectrode; HPLC)
• Immunohistochemistry (double and triple immunolabeling, confocal microscopy)

Funding:

Dr. Zhou’s research is funded by R01 grants from the National Institute on Drug Abuse and the National Institute of Mental Health and grants from private foundations.

Employment opportunities

To apply for a job in Dr. Zhou’s lab, please email your CV to fzhou3@utmem.edu. Patch clamp and/or molecular biology skills are required for postdoctoral research positions. Students are welcome.

Selected Publications:

1. Zhou F-M, Hablitz JJ (1999) Dopamine modulation of membrane and synaptic properties of interneurons in rat cerebral cortex. J Neurophysiol 81:967-976.

2. Zhou F-M, Hablitz JJ (1999) Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J Neurophysiol 82:2989-2999.

3. Aroniadou-Anderjaska V, Zhou F-M, Priest CA, Ennis M, Shipley MT (2000) Tonic and synaptically evoked presynaptic inhibition of sensory input to the rat olfactory bulb via GABAB heteroreceptors. J Neurophysiol 84:1194-1203.

4. Ennis M, Zhou FM, Ciombor KJ, Aroniadou-Anderjaska V, Hayar A, Borrelli E, Zimmer LA, Margolis F, Shipley MT (2001) Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals. J Neurophysiol 86:2986-97.

5. Dani JA, Ji D, Zhou F-M (2001) Synaptic plasticity and nicotine addiction. Neuron 31:349-352.

6. Zhou F-M, Liang Y, Dani JA (2001) Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nat Neurosci 4:1224-1229.

7. Zhou F-M, Wilson CJ, Dani JA (2002)Cholinergic interneuron characteristics and nicotinic properties in the striatum. J Neurobiol 53:590-605.

8. Zhou F-M, Wilson CJ, Dani JA (2003)Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. Neuroscientist9:23-36.

9. Zhang L, Zhou F-M, Dani JA (2004)Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release. Mol Pharmacol 66:538-44.

10. Dani JA, Zhou F-M (2004)Selective dopamine filter of glutamate striatal afferents. Neuron 42:522-524.

11. Zhou F-M, Liang Y, Salas R, Zhang L, De Biasi M, Dani JA (2005) Co-release of dopamine and serotonin from striatal dopamine terminals. Neuron 46:65-74.

12. Chen R, Tilley MR, Wei H, Zhou F-W, Zhou F-M, Hill ER, Wei H, Nottoli T, Han DD, Gu HH (2006) Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci USA103:9333-8.

13. Zhou F-M, Dani JA (2006) Antidepressants alter mesostriatal dopamine interactions with serotonin signaling. Current Psychiatry Reviews  2:453-461.

14. Zhou FW, Xu JJ, Zhao Y, LeDoux MS, Zhou F-M (2006) Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. J Neurophysiol 96:1581-91.

15. Zhou FW, Matta SG, Zhou F-M (2008) Constitutively active TRPC3 channels regulate basal ganglia output neurons. J Neuroscience 28:473-482.