Department of Pathology

University of Tennessee Health Science Center

Dr. Chuan-He Yang received his Ph.D. degree from Beijing Forestry University, Beijing, P.R. China in 1985.  He was a Postdoctoral Research Fellow at New York Medical College from 1992-1994 and at UT from 1994-1998.  

Research Interests:

Dr. Yang's research interests focus primarily on cell and molecular biology of interferon action.

Selected Publications:

Yang, C.H., Shi, W., Basu, L., Murti, A., Constantinescu, S.N., Blatt, L., Croze, E., Mullersman, J.E., and Pfeffer, L.M.  Direct association of STAT3 with the IFNAR1 signal transducer chain of the interferon-a receptor.  The Journal of Biological Chemistry, 271:8057-8061, 1996.

Pfeffer, L.M., Mullersman, J.E., Pfeffer, S.R., Murti, A., Shi, W., and Yang, C.H.  The role of STAT3 as an adaptor to couple phosphatidylinositol (PI)-3 kinase to the IFNAR1 chain of the type I IFN receptor.  Science, 276:1418-1420, 1997.

Yang, C.H., Murti, A., and Pfeffer, L.M.  STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for STAT3 in interferon signaling and biological activities.  Proc. Natl. Acad. Sci.  USA, 95:5568-5572, 1998.

Yang, C.H., Murti, A., Pfeffer, S.R., Basu, L., Kim, J.G., Pfeffer, L.M.  IFN a/b promotes cell survival by activating NF-kB.  Proc. Natl. Acad. Sci.  USA, 97:13631-13636, 2000.

Yang, C.H., Murti, A., Pfeffer, S.R., Kim, J.G., Donner, D.B., Pfeffer, L.M.  IFN a/B promotes cell survival by activating NF-kB through Phosphatidylinositol-3 kinase and Akt.  The Journal of Biological Chemistry, 276:13756-13761, 2001.