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Biography:
Dr. Strom received his MD, and a PhD in
Biochemistry, from the University of Chicago. He trained in
Pathology at Santa Clara Valley Medical Center in San Jose, CA, and at Columbia
Presbyterian Hospital in New York, and completed a Fellowship in Hematopathology
at the University of California Davis Medical Center. Before joining
the faculty in 2003, Dr. Strom held a Physician/Scientist position at St. Jude
Children’s Research Hospital.
Research Interests:
Our lab works on the
pathophysiology of the Wiskott-Aldrich Syndrome (WAS). Working with a murine
model for this X-linked immunodeficiency/thrombocytopenia, we have used a
retroviral vector to introduce the normal Wiskott-Aldrich syndrome gene (WAS)
into hematopoietic stem cells from WAS mice. This results in correction of key
features of the disease after transplantation of the gene-corrected cells into
WAS recipients. We went on to characterize in detail the immunologic and
hematologic features of the mouse model. We have found it to demonstrate a
number of deficiencies representative of clinical WAS. Our more recent
work is directed toward understanding how lack of the WAS gene product (WASP)
results in thrombocytopenia. This turns out to be highly relevant to the
more general question of how platelet consumption normally occurs, and sheds
light on the development of autoimmunity in this and other hematologic contexts.
Selected Publications:
Prislovsky, A, Bolen, AL,
Marathe, B, Hosni, A, Bolen, AL, Nimmerjahn, F, Ravetch, JV, Jackson, CW, Weiman,
D, and Strom, TS. Rapid platelet turnover in WASP(-) mice correlates with
increased ex vivo phagocytosis of opsonized WASP(-) platelets. Experimental
Hematology, in press, 2008.
Andreansky, S, Liu, H, Turner, S, McCullers, JA, Lang, R, Rutschman, R, Doherty,
PC, Murray, PJ, Nienhuis, AW, and Strom, TS. WASP- mice Exhibit Defective
Immune Responses to Influenza A Virus, Streptococcus pneumoniae, and
Mycobacterium bovis BCG. Experimental Hematology 33, 443-451 (2005).
Strom, TS, Liu, H, Andreansky,
S, Turner, S, Doherty, PC, Cunningham, JM, and Nienhuis, AW. Defects in T-cell
mediated immunity to influenza virus in murine Wiskott-Aldrich Syndrome are
corrected by oncoretroviral mediated gene transfer into repopulating
hematopoietic cells. Blood 102, 3108-3116 (2003).
Strom, TS, Gabbard, W, Kelly, P, Cunningham, JM,
and Nienhuis, AW. Functional correction of T cells derived from patients with
the Wiskott–Aldrich syndrome (WAS) by transduction with an oncoretroviral vector
encoding the WAS protein Gene Therapy 10, 803-809 (2003).
Strom, TS, Li, X, Cunningham,
JM, and Nienhuis, AW. Correction of the Murine Wiskott-Aldrich Syndrome (WAS)
phenotype by hematopoietic stem cell transplantation. Blood 99, 4626-4628
(2002). |
