Research Staff
 Karen Hasty, PhD,
holds the George Thomas Wilhelm Endowed Professorship in Orthopaedic Surgery
within the UT-Campbell Clinic Department of
Orthopaedic Surgery and is chief researcher in the Department. Her research is
currently funded by grants from the Arthritis Foundation, the Veteran's
Administration, and the National Institutes of Health. Dr. Hasty completed her
doctorate in anatomy (1981) and an Arthritis Foundation fellowship (1985) at the
University of Tennessee Health Science Center. A research biologist, Dr. Hasty
has been a reviewer for the Histochemical Journal; Journal of Cellular
Physiology; Journal of Clinical Investigation; Arthritis and Rheumatology;
Journal of Immunology; Journal of Biological Chemistry; Journal of Cell Biology;
Matrix; and Cartilage and Osteoarthritis for 16 years. She has published more
than 50 journal articles, has appeared in more than 75 abstracts and has written
segments in seven books.
Weikuan Gu, PhD joined the University in 2002 as an Assistant Professor. He
obtained his PhD in 1994 from Cornell University and completed postdoctoral studies
in 1996. At Cornell University, his field of study was plant geneticsand pathology. Dr. Gu has published 34 peer reviewed publications. His research
currently focuses on two areas: (a) positional cloning and functional studies of
spontaneous mutations of genes in mice using a newly developed
integrative strategy, which combines genomic resources and updated
biotechnologies, and (b) identification of genetic factors that regulate bone
density, bone structure, and susceptibility to arthritis. For characterization
of genes involved with bone metabolism, our
researchers are using the nanoindentation technology and genetic markers to map
the quantitative trait loci (QTL) of bone quality from a mouse F2 population. In
arthritis research, he is using the QTL mapping and microarray technology to
identify pathways that regulate resistance to the spontaneous arthritis in
IL-1ra deficient mice (funded by NIH, collaborating with Dr. J. Stuart at VA
Medical Center and Dr. K. Hasty).
In addition, he is Director for the DNA Discovery Core of the UTHSC Center of Genomics
and Bioinformatics. The core, which services the UT research and education community,
has the capacity of high throughput mutation/polymorphism screening.
|
