THADDEUS S. NOWAK, Ph.D.

Professor and Director of Research

Department of Neurology

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

855 Monroe Avenue, Room 415

Memphis, TN 38163

Tel: (901) 448-7384; Fax: (901) 448-7440;

Education

Ph.D. Institution: Massachusetts Institute of Technology

Postdoctoral: National Institute of Neurological Disorders and Stroke, Laboratory of Neurochemistry and Laboratory of Neuropathology and Neuroanatomical Sciences

Research Interests

Major interest is in the utility of changes in gene expression as markers for cellular pathology, and in the relationships between the responsible signal transduction pathways and physiological mechanisms underlying cell loss or recovery. Techniques include rodent models of cerebral ischemia, in situ and blot hybridization detection of nucleic acids, immunocytochemistry and immunoblot analyses of proteins. Current studies focus on the heat shock/stress response, induction of proto-oncogene transcription factors, and alternative splicing of microtubule-associated protein 2.

Links

Neurology - Thaddeus S. Nowak

Recent Publications

• Zhao Y, Xiao J, Ueda M, Wang Y, Hines M, Nowak TS Jr, Ledoux MS. Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous system. Neuroscience. 2008 Aug 13;155(2):439-53. Epub 2008 May 6. PMID: 18538941
• Hashimoto M, Zhao L, Nowak TS Jr. Temporal thresholds for infarction and hypothermic protection in Long-Evans rats: factors affecting apparent 'reperfusion injury' after transient focal ischemia. Stroke. 2008 Feb;39(2):421-6. Epub 2008 Jan 3. PMID: 18174482
• Kurasako T, Zhao L, Pulsinelli WA, Nowak TS Jr. Transient cooling during early reperfusion attenuates delayed edema and infarct progression in the Spontaneously Hypertensive Rat. Distribution and time course of regional brain temperature change in a model of postischemic hypothermic protection. J Cereb Blood Flow Metab. 2007 Dec;27(12):1919-30. Epub 2007 Apr 11. PMID: 17429346
• Ma J, Zhao L, Nowak TS Jr. Selective, reversible occlusion of the middle cerebral artery in rats by an intraluminal approach. Optimized filament design and methodology. J Neurosci Methods. 2006 Sep 30;156(1-2):76-83. Epub 2006 Apr 11. PMID: 16581135
• Zhao L, Nowak TS Jr. CBF changes associated with focal ischemic preconditioning in the spontaneously hypertensive rat. J Cereb Blood Flow Metab. 2006 Sep;26(9):1128-40. Epub 2006 Jan 11. PMID: 16407854
• Kamiya T, Jacewicz M, Nowak TS Jr, Pulsinelli WA. Cerebral blood flow thresholds for mRNA synthesis after focal ischemia and the effect of MK-801. Stroke. 2005 Nov;36(11):2463-7. Epub 2005 Oct 13. PMID: 16224091

view complete list of references (pubmed link)