KRISTIN HAMRE, Ph.D.

Assistant Professor

Department of Anatomy and Neurobiology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

855 Monroe Avenue, Suite 515

Memphis, TN 38163

Tel: (901) 448-2643; Fax: (901) 448-7193;

Lab: 220 Wittenborg Anatomy Building

Education

Ph.D. Institution: Department of Anatomy, University of Iowa, Iowa City, IA

Postdoctoral: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN (laboratory of Dr. Daniel Goldowitz)

Research Interests

There are 2 major foci of my research, both centered on the interaction between genetics and the nervous system. The first major focus is centered on examining the relationship between genetics and several ethanol-related phenotypes in both the developing embryo and the adult animal. This research uses both strategies that attempt to identify the critical genes in mediating a phenotype as well as the opposite strategy of determining the role of a specific gene in a phenotype using mutant mice. Both behavioral and anatomic phenotypes (e.g. cell death markers) are examined. The second major focus is examining how specific genes impact the development of various neuronal populations. In this approach the effect of a mutated gene, either in naturally-occurring or induced mutations, on the morphology of a specific structure or cell type is examined.

Recent Publications

• Hamre KM, Goldowitz D, Wilkinson S, Matthews DB. Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav Neurosci. 2007 Aug;121(4):665-78. PMID: 17663592
• Du X, Jensen P, Goldowitz D, Hamre KM. Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice. Dev Biol. 2007 May 15;305(2):430-8. Epub 2007 Feb 28. PMID: 17397818
• Mozhui K, Hamre KM, Holmes A, Lu L, Williams RW. Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice. Behav Genet. 2007 Jan;37(1):223-43. Epub 2006 Nov 28. PMID: 17131200
• Goldowitz D, Matthews DB, Hamre KM, Mittleman G, Chesler EJ, Becker HC, Lopez MF, Jones SR, Mathews TA, Miles MF, Kerns R, Grant KA. Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes. Alcohol Clin Exp Res. 2006 Jun;30(6):1066-78. PMID: 16737467
• Kralic JE, Criswell HE, Osterman JL, O'Buckley TK, Wilkie ME, Matthews DB, Hamre K, Breese GR, Homanics GE, Morrow AL. Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest. 2005 Mar;115(3):774-9. PMID: 15765150
• Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW. cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. Oncogene. 2004 Apr 29;23(20):3700-7. PMID: 15116101

view complete list of references (pubmed link)