ELDON E. GEISERT, Ph.D.

Professor

Department of Ophthalmology

Department of Anatomy and Neurobiology

Director, Vision Science Research Center

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

Hamilton Eye Institute

930 Madison Avenue, Suite 710

Memphis, TN 38163

Tel: (901) 448-7740; Fax: (901) 448-7193;

Education

Ph.D. Institution: University of Wisconsin, Madison, Department of Neuroscience

Postdoctoral: University of Wisconsin, Madison, Department of Psychology

Research Interests

The primary interests of this laboratory are to reveal the role of specific cell surface glycoproteins in the guidance of growing axons. Defining the mechanisms that facilitate and inhibit axonal growth leads to an understanding of the normal development of central nervous system and the molecular mechanisms that underlie the lack of axonal growth in the mature brain and spinal cord.

Using the methods of immunology, molecular biology, and protein chemistry, we are defining the proteins that facilitate and inhibit the interactions of growing axons with the environment of the developing and the adult brain. These molecules are being defined by producing monoclonal antibodies to membrane proteins and by using molecular biology to differentially identify the genes that are upregulated during the final maturation of the central nervous system. The functional role of these proteins is tested using tissue culture models and within the intact nervous system.

Links

Ophthalmology - Eldon E. Geisert

Recent Publications

• Dijkstra S, Kooij G, Verbeek R, van der Pol SM, Amor S, Geisert EE Jr, Dijkstra CD, van Noort JM, Vries HE. Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE. Neurobiol Dis. 2008 Sep;31(3):413-21. Epub 2008 Jun 5. PMID: 18586096
• Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J, Dragatsis I, Goldowitz D. A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. Genesis. 2007 Sep;45(9):560-9. PMID: 17868115
• Shapiro LA, Ng KL, Kinyamu R, Whitaker-Azmitia P, Geisert EE, Blurton-Jones M, Zhou QY, Ribak CE. Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex. Brain Struct Funct. 2007 Sep;212(2):133-48. Epub 2007 Sep 1. PMID: 17764016
• Pan Y, Brown C, Wang X, Geisert EE. The developmental regulation of CD81 in the rat retina. Mol Vis. 2007 Feb 7;13:181-9. PMID: 17327823
• Mohler ML, Kang GS, Hong SS, Patil R, Kirichenko OV, Li W, Rakov IM, Geisert EE, Miller DD. Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. J Med Chem. 2006 Sep 21;49(19):5845-8. PMID: 16970409
• Dijkstra S, Duis S, Pans IM, Lankhorst AJ, Hamers FP, Veldman H, Bär PR, Gispen WH, Joosten EA, Geisert EE Jr. Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury. Exp Neurol. 2006 Nov;202(1):57-66. Epub 2006 Jun 27. PMID: 16806185

view complete list of references (pubmed link)