DANIEL GOLDOWITZ, Ph.D.

Professor

Department of Anatomy and Neurobiology

Co-Director, Center for Genomics & Bioinformatics

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

855 Monroe Avenue, Suite 515

Memphis, TN 38163

Tel: (901) 448-7019; Fax: (901) 448-7193;

Lab: 532 Link Building

Education

Ph.D. Institution: University of California, Irvine, Department of Psychobiology

Postdoctoral: Harvard Medical School and Children's Hospital, Departments of Neuropathology and Neuroscience; Karolinska Institute, Department of Histology; University of Utah, College of Medicine, Department of Anatomy

Research Interests

Mechanisms underlying mammalian CNS development are a major focus of this laboratory. Two principle experimental approaches are used to study the development of the mammalian brain. One is the study of neurological mutations in mice and dogs that offers the possibility of determining the genes involved in brain development. The other is the experimental embryological techniques of mouse aggregation chimeras. This approach allows the identification of cellular sites of mutant gene action and the tracing of cell lineage. The neurohistological techniques we employ to study this problem are in situ hybridization, immunocytochemistry, and image analysis. We also use embryo manipulation, gene mapping using special breeding schemes and microsatellite markers, and extreme thoughtfulness in our studies of brain development.

Recent Publications

• Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J. 2008 Dec 17;27(24):3221-34. Epub 2008 Nov 27. PMID: 19037259
• Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A. CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse. Neurobiol Dis. 2009 Mar;33(3):315-30. Epub 2008 Nov 6. PMID: 19027857
• Yang GS, Banks KG, Bonaguro RJ, Wilson G, Dreolini L, de Leeuw CN, Liu L, Swanson DJ, Goldowitz D, Holt RA, Simpson EM. Next generation tools for high-throughput promoter and expression analysis employing single-copy knock-ins at the Hprt1 locus. Genomics. 2009 Mar;93(3):196-204. Epub 2008 Dec 3. PMID: 18950699
• Crusio WE, Goldowitz D, Holmes A, Wolfer D. Standards for the publication of mouse mutant studies. Genes Brain Behav. 2009 Feb;8(1):1-4. Epub 2008 Sep 6. No abstract available. PMID: 18778401
• D'Souza CA, Chopra V, Varhol R, Xie YY, Bohacec S, Zhao Y, Lee LL, Bilenky M, Portales-Casamar E, He A, Wasserman WW, Goldowitz D, Marra MA, Holt RA, Simpson EM, Jones SJ. Identification of a set of genes showing regionally enriched expression in the mouse brain. BMC Neurosci. 2008 Jul 14;9:66. PMID: 18625066
• Matthews DB, Morrow AL, O'Buckley T, Flanigan TJ, Berry RB, Cook MN, Mittleman G, Goldowitz D, Tokunaga S, Silvers JM. Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice. Alcohol. 2008 Sep;42(6):469-76. Epub 2008 Jul 2. PMID: 18599253

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