DANIEL GOLDOWITZ, Ph.D.

Professor

Department of Anatomy and Neurobiology

Co-Director, Center for Genomics & Bioinformatics

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

855 Monroe Avenue, Suite 515

Memphis, TN 38163

Tel: (901) 448-7019; Fax: (901) 448-7193;

Lab: 532 Link Building

Education

Ph.D. Institution: University of California, Irvine, Department of Psychobiology

Postdoctoral: Harvard Medical School and Children's Hospital, Departments of Neuropathology and Neuroscience; Karolinska Institute, Department of Histology; University of Utah, College of Medicine, Department of Anatomy

Research Interests

Mechanisms underlying mammalian CNS development are a major focus of this laboratory. Two principle experimental approaches are used to study the development of the mammalian brain. One is the study of neurological mutations in mice and dogs that offers the possibility of determining the genes involved in brain development. The other is the experimental embryological techniques of mouse aggregation chimeras. This approach allows the identification of cellular sites of mutant gene action and the tracing of cell lineage. The neurohistological techniques we employ to study this problem are in situ hybridization, immunocytochemistry, and image analysis. We also use embryo manipulation, gene mapping using special breeding schemes and microsatellite markers, and extreme thoughtfulness in our studies of brain development.

Recent Publications

• Matthews DB, Morrow AL, O'Buckley T, Flanigan TJ, Berry RB, Cook MN, Mittleman G, Goldowitz D, Tokunaga S, Silvers JM. Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL/6J male mice, but not DBA/2J or A/J male mice. Alcohol. 2008 Jul 1; [Epub ahead of print] PMID: 18599253
• Matthews DB, Chesler EJ, Cook MN, Cockroft J, Philip VM, Goldowitz D. Genetic mapping of vocalization to a series of increasing acute footshocks using b6.a consomic and b6.d2 congenic mouse strains. Behav Genet. 2008 Jul;38(4):417-23. Epub 2008 Jun 6. PMID: 18535899
• Mittleman G, Goldowitz D, Heck DH, Blaha CD. Cerebellar modulation of frontal cortex dopamine efflux in mice: relevance to autism and schizophrenia. Synapse. 2008 Jul;62(7):544-50. PMID: 18435424
• Reiner A, Del Mar N, Deng YP, Meade CA, Sun Z, Goldowitz D. R6/2 neurons with intranuclear inclusions survive for prolonged periods in the brains of chimeric mice. J Comp Neurol. 2007 Dec 20;505(6):603-29. PMID: 17948889
• Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J, Dragatsis I, Goldowitz D. A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein. Genesis. 2007 Sep;45(9):560-9. PMID: 17868115
• Hamre KM, Goldowitz D, Wilkinson S, Matthews DB. Screening for ENU-induced mutations in mice that result in aberrant ethanol-related phenotypes. Behav Neurosci. 2007 Aug;121(4):665-78. PMID: 17663592

view complete list of references (pubmed link)