CHARLES W. LEFFLER, Ph.D.

Professor

Department of Physiology

The University of Tennessee College of Medicine

Address

The University of Tennessee Health Science Center

309 Nash Research Building

894 Union Avenue

Memphis, TN 38163

Tel: (901) 448-7122; Fax: (901) 448-7126;

Education

Ph.D. Institution: University of Florida, Department of Zoology

Postdoctoral: University of Florida, Department of Physiology

Research Interests

Research in the laboratory concentrates on newborn cardiovascular regulation, with particular emphasis on control of cerebral circulation. The primary focus of this research involves autocrine/paracrine control of the newborn cerebral microvasculature during physiologically stressful and pathological situations, and the cellular mechanisms involved in such control.

Links

Physiology - Charles Leffler

Recent Publications

• Narayanan N, Leffler CW, Daley ML. Assessment of cerebrovascular resistance with a model of cerebrovascular pressure transmission. Med Eng Phys. 2008 Aug 6; [Epub ahead of print] PMID: 18693128
• Narayanan N, Leffler CW, Daley ML. Influence of hypercapnic vasodilation on cerebrovascular autoregulation and pial arteriolar bed resistance in piglets. J Appl Physiol. 2008 Jul;105(1):152-7. Epub 2008 Apr 24. PMID: 18436696
• Parfenova H, Leffler CW. Cerebroprotective functions of HO-2. Curr Pharm Des. 2008;14(5):443-53. Review. PMID: 18289071
• Holt DC, Fedinec AL, Vaughn AN, Leffler CW. Age and species dependence of pial arteriolar responses to topical carbon monoxide in vivo. Exp Biol Med (Maywood). 2007 Dec;232(11):1465-9. PMID: 18040071
• Li A, Xi Q, Umstot ES, Bellner L, Schwartzman ML, Jaggar JH, Leffler CW. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels. Circ Res. 2008 Feb 1;102(2):234-41. Epub 2007 Nov 8. PMID: 17991880
• Kanu A, Leffler CW. Carbon monoxide and Ca2+-activated K+ channels in cerebral arteriolar responses to glutamate and hypoxia in newborn pigs. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3193-200. Epub 2007 Aug 31. PMID: 17766483

view complete list of references (pubmed link)