Ronald F. Pfeiffer, M.D.
Professor and Vice Chair, Department of Neurology
Director, Division of Neurodegenerative Diseases
Education
|
B.S. M.D. |
University of Nebraska-Lincoln University of Nebraska Medical Center |
1969 1973 |
Post-Graduate Training
|
Intern Resident |
Walter Reed Army Med. Center, Int. Med. Walter Reed Army Med. Center, Neurology |
1974 1977 |
Professional Experience
|
Assistant Professor Associate Professor Professor Professor Vice Chair |
U. of Nebraska, Neurology and Pharmacology U. of Nebraska, Neurology and Pharmacology U. of Nebraska, Medicine and Pharmacology U. of Tennessee, Neurology U. of Tennessee, Neurology |
1980 1985 1993 1994 1996 |
Professional Certification & Licensing
|
Diplomate, American Board of Psychiatry and Neurology Medical License Medical License |
Nebraska Tennessee |
1980 1994 |
Clinical Subspecialty Expertise
Parkinson's Disease
Research Interests
My research interests focus on Parkinson’s disease. As a member of the Parkinson Study Group and on an independent basis I have participated in clinical trials of numerous experimental antiparkinson medications. I have a particular interest in nonmotor dysfunction in Parkinson’s disease, especially gastrointestinal dysfunction. I have been involved in investigations studying both the pathophysiology and treatment of this component of Parkinson’s disease. The genetic aspects of Parkinson’s disease have also been an area of research activity.
Representative Publications
Books Edited (2004-2006):
Quigley EMM, Pfeiffer RF (eds). Neurogastroenterology. Butterworth Heinemann:Philadelphia, 2004.
Pfeiffer RF, Bodis-Wollner I (eds). Parkinson’s Disease and Non-Motor Dysfunction. Humana Press:Totowa, NJ, 2005.
Ebadi M, Pfeiffer RF (eds). Parkinson’s Disease. CRC Press:Boca Raton, FL, 2005.
Book Chapters (2004-2006):
Pfeiffer RF, Quigley EMM: Gastrointestinal Dysfunction in Diseases of the Cerebral Hemispheres and Movement Disorders. In: Quigley EMM, Pfeiffer RF (eds): Neurogastroenterology. Elsevier:Philadelphia. pp 59-81, 2004.
Pfeiffer RF: Gastrointestinal Dysfunction in Spinal Cord Disease. In: Quigley EMM, Pfeiffer RF (eds): Neurogastroenterology. Elsevier:Philadelphia. pp 101-112, 2004.
Pfeiffer RF: Parkinsonism. In: Rakel RE, Bope ET (eds): Conn’s Current Therapy, 2004. WB Saunders:New York. pp 989-995, 2004.
Pfeiffer RF: Neurogenic Dysphagia. In: Bradley WG, Daroff RB, Fenichel GM, Jankovic J (eds): Neurology in Clinical Practice (Fourth Edition). Elsevier:Philadelphia. pp 165-176, 2004.
Pfeiffer RF: Wilson’s Disease. In: Watts RL, Koller WC (eds): Movement Disorders. Neurologic Principles and Practice (Second Edition). McGraw-Hill:New York. pp. 779-797, 2004.
Pfeiffer RF: Intestinal Dysfunction. In: Pfeiffer RF, Bodis-Wollner I (eds): Parkinson’s Disease and Non-Motor Dysfunction. Humana Press:Totowa, NJ. pp. 115-125, 2005.
Ford B, Pfeiffer RF: Pain Syndromes and Disorders of Sensation. In: Pfeiffer RF, Bodis-Wollner I (eds): Parkinson’s Disease and Non-Motor Dysfunction. Humana Press:Totowa, NJ. pp. 255-267, 2005.
Pfeiffer RF: Gastrointestinal Dysfunction in Parkinson’s Disease. In: Ebadi M, Pfeiffer RF (eds): Parkinson’s Disease. CRC Press:Boca Raton, FL. pp. 259-273, 2005.
Pfeiffer RF: Neurotransplantation in Parkinson’s Disease. In: Ebadi M, Pfeiffer RF (eds): Parkinson’s Disease. CRC Press:Boca Raton, FL pp. 767-776, 2005.
Pfeiffer RF: The Phenotypic Spectrum of Parkinson’s Disease. In: LeDoux M (ed.): Animal Models of Movement Disorders. Academic Press:San Diego. pp. 127-137, 2005.
Lewitt P and Pfeiffer RF: Neurologic Aspects of Wilson’s Disease: Clinical Manifestations and Treatment Considerations. In: Jankovic J, Tolosa E (eds): Parkinson’s Disease and Movement Disorders (Fifth Edition).Lippincott Williams & Wilkins:Philadelphia. (in press).
Pfeiffer RF: Multiple System Atrophy. In: Melamed E, Koller W (Eds): Parkinson’s Disease and Related Disorders (Handbook of Clinical Neurology). Elsevier:Philadelphia. (in press).
Pfeiffer RF: Neurology of Gastroenterology and Hepatology. In: Schapira AHV (Ed.): Neurology: Basic and Clinical Neurosciences. Elsevier:Philadelphia. (in press).
Pfeiffer RF: Bladder and Sexual Dysfunction. In: Schapira AHV (Ed.): Neurology: Basic and Clinical Neurosciences. Elsevier:Philadelphia. (in press).
Journal Articles (2004-2006):
Marras C, Lang A, Krahn M, Tomlinson G, Naglie G, and the Parkinson Study Group: Quality of life in early Parkinson’s disease: impact of dyskinesias and motor fluctuations. Movement Disorders 19:22-28, 2004.
Parkinson Study Group: The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD. Neurology 62:330-332, 2004.
Noyes K, Dick A, Holloway RG, and the Parkinson Study Group: Pramipexole vs levodopa as initial treatment for Parkinson’s disease. A randomized clinical-economic trial. Medical Decision Making 24:472-485, 2004.
Zimprich A, Muller-Myhsok B, Farrer M, Leitner P, Sharma M, Hulihan M, Lockhart P, Strongosky A, Kachergus J, Calne DB, Stoessl J, Uitti RJ, Pfeiffer RF, Trenkwalder C, Homann N, Ott E, Wenzel K, Asmus F, Hardy J, Wszolek Z, Gasser T: The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. American Journal of Human Genetics 74:11-19, 2004.
Wszolek ZK, Pfeiffer RF, Tsuboi Y, Uitti RJ, McComb RD, Stoessl AJ, Strongosky AA, Zimprich A, Müller-Myhsok B, Farrer MJ, Gasser T, Calne DB, Dickson DW: Autosomal dominant parkinsonism associated with variable synuclein and tau pathology: Update on studies of Family D (Western Nebraska). Neurology 62:1619-1622, 2004.
Pankratz N, Uniacke SK, Halter CA, Rudolph A, Shults CW, Conneally PM, Foroud T, Nichols WC; Parkinson Study Group: Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci. Neurology 62:1616-1618, 2004.
Nichols WC, Uniacke SK, Pankratz N, Reed T, Simon DK, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T; Parkinson Study Group: Evaluation of the role of Nurr1 in a large sample of familial Parkinson’s disease. Movement Disorders 19:649-655, 2004.
Parkinson Study Group: Pramipexole vs. levodopa as initial treatment of Parkinson’s disease. Archives of Neurology 61:1044-1053, 2004.
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Müller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T: Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44:601-607, 2004.
Marras C, McDermott MP, Rochon PA, Tanner CM, Naglie G, Rudolph A, Lang AE, and the Parkinson Study Group: Survival in Parkinson disease. Thirteen-year follow-up of the DATATOP cohort. Neurology 64:87-93, 2005.
Nichols WC, Pankratz N, Hernandez D, Paisan-Ruiz C, Jain S, Halter C, Michaels VE, Reed T, Rudolph A, Shults CW, Singleton A, Foroud T; Parkinson Study Group-PROGENI investigators: Genetic screening for a single common LRRK2 mutation in familial Parkinson’s disease. Lancet 365:410-412, 2005.
Nausieda P, Pfeiffer RF, Tagliati M, Kastenholz KV, DeRoche C, Slevin JT: A multicenter, open-label, sequential study comparing preferences for carbidopa-levodopa orally disintegrating tablets and conventional tablets in subjects with Parkinson’s disease. Clinical Therapeutics 27:58-63, 2005
Pfeiffer RF: Neurological dysfunction in gastrointestinal diseases. Continuum 11:59-84, 2005.
Pfeiffer RF: A promising new technology for Parkinson’s disease. Neurology 65(Suppl 1):S6-S10, 2005.
Pankratz N, Byder L, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T, Nichols WC and the Parkinson Study Group-PROGENI Investigators: Presence of an APOE4 allele results in significantly earlier onset of Parkinson disease and a higher risk of PD with dementia. Movement Disorders 21:45-49, 2006.
Pfeiffer RF, Gutmann L, Hull KL Jr, Bottini PB, Sherry JH, and the APO302 Study Investigators: Continued efficacy and safety of subcutaneous apomorphine in patients with advanced Parkinson’s disease. Parkinsonism and Related Disorders (in press)