Molecular Sciences Faculty Directory
Kui Li, Ph.D.
Associate Professor
858 Madison Ave.
Room 401
Memphis, TN 38163
Email: kli1@utmem.edu
Phone: 901-448-2571
Fax: 901-448-7360
Research Interests
Work in my lab is focused on understanding virus-host interactions during infections of positive strand RNA viruses. We are particularly interested in innate immunity to hepatitis C virus and related flaviviruses, and Severe Acute Respiratory Syndrome coronavirus. By defining host factors/responses to these viruses that contribute to limiting viral replication and spread as well as viral mechanisms that counteract host protective responses, we hope to provide new knowledge that will help design new measures to treat and/or prevent these viral infections. Another area of interest is to characterize novel components of cellular innate antiviral pathways.
Recent Publications
- Chen ZH, Benureau Y, Rijnbrand R, Yi JZ, Wang T, Walters L, Lanford RE, Weinman SA, Lemon SM, Martin A, and Li K. 2007. GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS. J. Virol., 81: 964-976.
- Liu P, Jamaluddin M, Li K, Garofalo RP, Casola A and Brasier AR. 2007. Retinoic acid inducible gene-I mediates early anti-viral response and Toll like receptor 3 expression in respiratory syncytial virus -infected airway epithelial cells. J. Virol., 81: 1401-1411.
- Ishida H, Li K, Yi M, and Lemon SM. 2007. P21-activated Kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in hepatoma cells. J. Biol. Chem., 282:11836-11848.
- Yang Y, Liang YQ, Qu L, Chen ZM, Yi M, Li K, and Lemon SM. 2007. Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor. Proc. Natl. Acad. Sci. USA., 104:7253-7258.
- Chen ZH, Rijnbrand R, Jangra R, Devaraj SG, Qu L, Ma YH, Lemon SM, and Li K. 2007. Ubiquitination and proteasomal degradation of interferon regulatory factor-3 induced by Npro from a cytopathic bovine viral diarrhea virus. Virology, 366: 277-292.
- Devaraj SG, Wang N, Chen ZB, Chen ZH, Tseng M, Barretto N, Lin R, Peters CJ, Tseng CT, Baker SC, and Li K. 2007. Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J. Biol. Chem., 282:32208-32221.
- Bao X, Liu T, Shan Y, Li K, Garofalo RP, and Casola A. 2008. Human Metapneumovirus glycoprotein G inhibits innate immune responses. PLoS Pathog., 4(5): e1000077.
- Xin LJ, Li K, and Soong L. 2008. Down-regulation of dendritic cell signaling pathways by Leishmania amazonensis amastigotes. Mol. Immunol., 45:3371-3382.
- Liao S, Bao X, Liu T, Lai S, Li K, Garofalo RP, and Casola A. 2008. Role of retinoic acid-inducible gene I in human Metapneumovirus-induced cellular signaling. J. Gen. Virol., 89:1978-1986.
- Liu P, Li K, Garafalo RP, and Brasier AR. 2008. RSV-induces RelA release from cytoplasmic 100 kDa NF-?B2 complexes via a novel retinoic acid inducible gene-I-NF-?B inducing kinase (NIK) signaling pathway. J. Biol. Chem., 283:23169-23178
- Liang YQ, Ishida H, Lenz O, Lin TI, Nyanguile O, Simmen K, Pyles R, Bourne N, Yi M, Li K, and Lemon SM. 2008. Antiviral suppression versus restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors. Gastroenterology, published online July 22, 2008.
- Preiss S, Thompson A, Chen XB, Rodgers S, Markovska V, Desmond P, Visvanathan K, Li K, Locarnini S, and Revill P. 2008. Characterization of the innate immune signaling pathways in hepatocyte cell lines. J. Viral Hepat., published online July 28, 2008.
Education
- Ph.D., Beijing Medical University, 1999
- M.D., Beijing Medical University, 1994
