Sepsis
Original Publications
Invited Editorials and
Letters
Invited Publications
Book Chapters
Meduri GU, Kanangat S, Stefan J, Tolley E,
Schaberg S. Cytokines IL-1ß, IL-6, and TNF-a enhance in vitro growth
of bacteria. Am J Resp Crit Care Med 1999; 160: 961-967.
PDF version
available - Linked by permission of the American Thoracic Society
Kanangat S, Meduri GU, Tolley E, Patterson DR, Meduri CU, Pak C, Schaberg
S. Effects of cytokines and endotoxin on the intracellular growth and survival
of bacteria. Infection and Immunity 1999; 67: 2834-2840.
Meduri GU. An historical review of glucocorticoid
treatment in sepsis. Disease pathophysiology and the design of treatment
investigation. Sepsis 1999; 3: 21-38.
Meduri GU, Kanangat S, Tolley E, Patterson
DR, Meduri CU, Pak C, Bronze M, Schaberg S. Effects of glucocorticoids on
the intracellular growth of bacteria in lipopolysaccharide-primed human
monocytic cells. (Submitted)
Meduri GU, Tolley EA, Chrousos G, Stentz
F. The effects of prolonged methylprednisolone treatment on dysregulated
systemic inflammation in patients with unresolving ARDS: time dependent
correction of immune system glucocorticoid resitance. (Submitted).
Kanangat S, Meduri GU, Bronze M, Postlethwaite A, Tolley E, Stentz F Schaberg S. Enhanced extracellular growth of staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin-1ß and IL-1receptor antagonist [IL-1ra]. J Infect Dis 2001; 183: 65-69.
Invited
Editorials and Letters
Meduri GU, Kanangat S. Glucocorticoid treatment
of sepsis and ARDS: Time for a critical reappraisal. Crit Care Med 1998;
26: 630-633
Meduri GU, Chrousos GP. Duration of glucocorticoid
treatment and outcome in sepsis: is the right drug used the wrong way? Chest
1998; 114: 355-360.
Meduri GU. Septic Shock: new understanding in the relationship between exaggerated
host defense response and endogenous glucocorticoid action. 27Th Educational
and Scientific Symposium of the Society of Critical Care Medicine, Feb 4-8,1998,
San Antonio, Texas.
Meduri GU. A paradigm shift: the bidirectional effect of Inflammation on
bacterial growth. In Sepsis and Organ Dysfunction. The challenge continues.
A.E. Baue, G. Berlot, A. Gullo, and JL. Vincent Editors. Springer-Verlag
Berlin 1999; pages 145-154.
Meduri GU. The bi-directional effect of inflammation on bacterial growth: a new insight into the role of glucocorticoids in the resolution of severe infections. Perspective on Critical Care Infectious Diseases – Evolving concepts in sepsis and septic shock. Editors: P. Q. Eichacker and J Pugin. Kluwer Academic Publishers 2001; pages 111-128.
Memphis
Lung Research Program
University of Tennnessee Health Science Center
Coleman College of Medicine
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