ARDS publications

Acute Respiratory Distress Syndrome (ARDS)

Original Publications

Invited Editorials and Letters

Invited Publications

Book Chapters

Original Publications

Meduri GU, Belenchia JM, Estes RJ, Leeper KV, Wunderink RG, Eltorky M. Fibroproliferative phase of ARDS. Clinical findings and effects of corticosteroids. Chest 1991; 100: 943-952. (with editorial)

Meduri GU, Stover DE, Greeno R, Nash T, Zaman MB. Bilateral bronchoalveolar lavage in the diagnosis of opportunistic pulmonary infections. Chest 1991; 100: 1272-1276.

Winer-Muram HT, Rubin SA, Ellis JV, Jennings SG, Arheart KL, Leeper KV, Wunderink RG, Meduri GU. Pneumonia and ARDS in the ventilated patient: diagnostic accuracy of the chest radiograph. Radiology 1993; 188: 479-485.

Meduri GU. Late Adult Respiratory Distress Syndrome. New Horizons 1993; 1: 563-577.

Meduri GU, Chinn AJ. Fibroproliferation in late ARDS: pathophysiology, clinical and laboratory manifestations and response to corticosteroid rescue treatment. Chest 1994; 105: 127S-129S.

Meduri GU, Chinn AJ, Leeper KV, Wunderink RG, Tolley E, Winer-Muram HT, Khare V, Eltorky M. Corticosteroid rescue treatment of progressive fibroproliferation in late ARDS. Patterns of responders of outcome. Chest 1994; 105: 1516-1527.

Meduri GU, Headley S, Stentz F, Kohler G, Tolley E, Leeper KV, Umberger R. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 and IL-6 are consistent and efficient predictors of outcome over time. Chest 1995; 107: 1062-1073.
PDF version available -Reprinted with permission from American College of Chest Physicians

Meduri GU, Headley S, Stentz F, Kohler G, Tolley E, Postlethwaite A. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts a poor outcome in ARDS. Chest 1995; 108: 1303-1314.
PDF version available - Reprinted with permission from American College of Chest Physicians

Meduri GU, Headley S, Tolley E, Stentz F, Kohler G, Postlethwaite A. Plasma and BAL cytokine response to corticosteroid rescue treatment in late ARDS. Chest 1995; 108: 1315-1325.
PDF version available - Reprinted with permission from American College of Chest Physicians

Meduri GU, Eltorky M, Winer-Muram HT. Fibroproliferative phase of late ARDS. Seminars in Respiratory Infections 1995; 10: 152-173.
Abstract

Meduri GU. The host defense response in the progression and outcome of ARDS. Pathophysiological correlations and response to glucocorticoid treatment. Eur Respir J. 1996; 9: 2650-2670.
Abstract

Headley S, Tolley E, Meduri GU. Infections and the inflammatory response in acute respiratory distress syndrome. Chest 1997; 111: 1306-1321.
PDF version available - Reprinted with permission from American College of Chest Physicians

Meduri GU, Headley S, Golden E, Carson S, Umberger R, Kelso T, Tolley E. Prolonged methylprednisolone treatment improves lung function and outcome of unresolving ARDS. A randomized, double-blind, placebo-controlled trial. JAMA 1998; 280: 159-165. (with editorial)
Full-text - Available for University of Tennessee, Memphis only (Linked by permission of American Medical Association)
Abstract

Meduri GU, Reddy R, Stanley T, El-Zeky F. Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling. Am J Resp Crit Care Med 1998; 158: 870-875.
Linked by permission of the American Thoracic Society [PDF file is in “Digital Article Retrieval” folder, in the “AJRCCM” subfolder: file ends in 158-1.]

Meduri GU, Tolley E, Chinn A, Stentz F, Postlethwaite A. Procollagen type I and III amino-terminal propetide levels during ARDS and in response to methylprednisolone treatment. Am J Resp Crit Care Med 1998; 158: 1432-1441.
PDF version available - Linked by permission of the American Thoracic Society

Meduri GU. Levels of evidence for the pharmacological effectiveness of prolonged methylprednisolone treatment in unresolving ARDS. Chest 1999; 116:116S-118S.
PDF version available - Reprinted with permission from American College of Chest Physicians

Meduri GU. New rationale for glucocorticoid treatment in septic shock. Journal of Chemotherapy. 1999; 11:447-456.

Janz TG, Madan R, Marini JJ, Summer WR, Meduri GU, Smith RM, Epler GR, Schnader. Clinical Conference on Management Dilemmas. Progressive infiltrates and respiratory failure. Chest 2000; 117: 562-572.
PDF version available - Reprinted with permission from American College of Chest Physicians

Meduri GU, Tolley EA, Chrousos G, Stentz F. The effects of prolonged methylprednisolone treatment on dysregulated systemic inflammation in patients with unresolving ARDS: time dependent correction of immune system glucocorticoid resitance. (Submitted).

Stentz F, Tolley EA, Chrousos G, Meduri GU. Activation and regulation of systemic inflammation during acute respiratory distress syndrome. Interaction between nuclear factor-kB and glucocorticoid receptors and its effect on the transcription of inflammatory cytokines. (Submitted).

Yates C R, Vysokanov A, Mukherjee A, Ludden T M, Tolley E A, Meduri G U and Dalton J T. Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: A population pharmacokinetic study. J Clin Pharmacol 2001; 451: 1-10.

Invited Editorials and Letters

Meduri GU. Host defense response and outcome in ARDS. Chest 1997; 112: 1154-1158.

Tolley E, Meduri GU, Headley S, Golden E, Carson S, Umberger R. Methylprednisolone for unresolving ARDS. JAMA 1998; 280: 2074 (letter)
Full-text - Available for University of Tennessee, Memphis only (Linked by permission of American Medical Association)

Invited Publications

Meduri GU. Levels of evidence for the pharmacological effectiveness of prolonged methylprednisolone treatment in unresolving acute respiratory distress syndrome. Minerva Anestesiologica 1999; 65:193-196.

Book Chapters

Meduri GU. The role of the host defense response in the progression and outcome of ARDS. Yearbook of Intensive Care Medicine; JL Vincent Editor. Springer-Verlag Berlin 1998; 38-55.

Meduri GU. Pathophysiology of unresolving ARDS. In Proceeding of the 13th Postgraduate Course In Critical Care Medicine. A. Gullo Editor. Springer-Verlag Berlin 1998; pages 693-710.

Meduri GU. Rationale for glucocorticoid treatment in septic shock and unresolving ARDS.In Multiple Organ Failure. Editors: Baue AE, Faise E, and Fry D. Springer-Verlag New York. 2000; pages:514-523.

Meduri GU. Corticosteroid treatment in unresolving ARDS. Molecular and cellular biology of critical care medicine: acute lung injury. Editor: H Wong. Kluwer Academic Publishers 2001 (in press).