|
|
|
|
|
College
of Graduate Health SciencesIntegrated Program in Biomedical Sciences |
|||||||
|
Molecular Therapeutics and Cell Signaling
Secondary Appointment: Identification of motifs in the human beta-1-adrenergic receptor that are involved in its coupling to G proteins, internalization, recycling, and resensitization after agonist exposure.
Secondary Appointment: Cell Biology and Biochemistry Taosheng Chen, Ph.D., Assistant Member, Dept. of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital taoscheng.chen@stjude.org Secondary Appointment: Cancer Biology and Developmental Biology Regulation of PXR and drug metabolism; regulation of PAX3-FKHR in alveolar rhabdomyosarcoma.
Secondary Appointment: Cell Biology and Biochemistry Control of genes regulating fat metabolism, concentrating on the control of fatty acid oxidation in liver and heart in diabetes, during fasting and in the normal, fed state.
Secondary Appointments: Neuroscience Modulation of ion channel function by alcohol and other small amphiphiles; Role of membrane lipids.
Secondary Appointments: Genetics, Functional Genomics and Proteomics Regulation of hepatic lipid/lipoprotein synthesis and secretion by insulin in obesity and type II diabetes; Regulation of Sterol-Regulatory-Element Binding Protein-1c (SREBP-1c) transcription by insulin, cyclic-AMP, and polyunsaturated fatty acids.
Secondary Appointments: Microbial Pathogenesis, Immunology and Inflammation Role of the Y-box binding protein, YB-1, in cell proliferation.
Secondary Appointments: Molecular, Cellular, and Systems Physiology Role of nitric oxide in vascular remodeling.
Secondary Appointments: Molecular, Cellular, and Systems Physiology Cellular and molecular mechanisms of neurohumoral interactions involved in vascular smooth muscle cell hyperplasia and hypertrophy and hypertension.
Secondary Appointments: Neuroscience Neurochemical, neuroanatomical, and biobehavioral alterations resulting
from Rennolds S. Ostrom, Ph.D., Assistant Professor, Dept. of Pharmacology, rostrom@uthsc.edu Secondary Appointments: Cell Biology and Biochemistry Investigation of how cells “pre-arrange” multiple signaling components in G protein-coupled receptor signal transduction cascades with focus on caveolae and lipid rafts as centers for such organization.
Secondary Appointments: Molecular, Cellular, and Systems Physiology Mechanisms by which hormones regulate gene expression in diabetes, hyperthyroidism and obesity.
Secondary Appointment: Molecular, Cellular and Systems Physiology Hematopoietic stem cell biology and gene therapy for hemoglobin disorders.
Secondary Appointments: Genetics, Functional Genomics and Proteomics Mechanisms of transcriptional and post-transcriptional regulation of homeobox genes Msx1/3.
Secondary Appointments: Neuroscience Nicotine self-administration-induced plasticity in stress-reponsive brain systems: involvement of genes, neurotransmitters, and hormones. Alex Sparreboom, Ph.D., Associate Member, Depart. Of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, alex.sparreboom@stjude.org Secondary Appointment: Cell Biology and Biochemistry Role of solute carriers in renal and hepatic anticancer drug clearance; Genetic factors contributing to interindividual variability in anticancer drug disposition.
Secondary Appointments: Neuroscience Neural mechanisms of drug addiction.
Secondary Appointment: Cancer and Development Biology Use of preclinical models that study the pharmacokinetics and pharmacodnamics of novel anticancer drugs to enhance the design of clinical trials in children with cancer.
Lab Location: VA Medical Center Room BB129 Our work concerns the Wiskott-Aldrich Syndrome, an x-linked immunodeficiency and thrombocytopenia. We have used retroviral vectors to gene correct the syndrome in a mouse model and are currently making improvements in the efficacy and safety of this technique while also studying the pathogenesis of both aspects of the phenotype. Wen Lin Sun, Ph.D., Assistant Professor, Department of Pharmacology, wsun5@uthsc.edu Secondary Appointment: Neuroscience Neurobiological mechanisms underlying drug addiction. Regulation of synaptic transmission and neuronal excitability by localized signaling systems.
Secondary Appointments: Cell Biology and Biochemistry Cell signaling by phospholipid growth factors.
Secondary Appointment: Neuroscience Dopamine and serotonin systems in the brain and their involvement in
neuropsychiatric disorders. Revised 18 August 2008
|
||||||
| Copyright © 2003 The University of Tennessee Health Science Center · College of Graduate Health Sciences · 930 Madison Ave., Suite 836 · Memphis, Tennessee 38163 · Telephone 901-448-5538 · Fax 901-448-1488 · Webmaster | |