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College
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Microbial Pathogenesis, Immunology, and InflammationElisabeth Adderson, M.D., Associate Member, Dept. of Infectious Disease, Elisabeth.adderson@stjude.org Secondary Appointments:
Secondary Appointments: Genetics, Functional Genomics and Proteomics Molecular mechanisms of retrovirus entry and infection; Design and development of viral vectors for anti-cancer human gene therapy.
Secondary Appointments: Genetics, Functional Genomics and Protemoics Characterization of the interaction between pathogenic Chlamydial species and their hosts during acute and persistent disease.
Secondary Appointment: Genetics, Functional Genomics and Proteomics Genetic analysis of Vibrio cholerae and Francisella tularensis pathogenesis
Secondary Appointment: Genetics, Functional Genomics and Proteomics Secondary Appointment: Immune-based cellular mechanisms that drive autoimmunity with emphasis
on animal models that provide the whole organ systems with which to study
these complex processes.
Secondary Appointments: Genetics, Functional Genomics and Proteomics Cell and molecular biology of Chlamydia pathogenesis.
Secondary Appointment: Molecular Therapeutics and Cell Signaling JNK and p38 MAP kinase (MAPK) pathway in innate and adaptive immunity; Sphingosine 1-phosphate (S1P) pathway in T cell trafficking and immune responses; molecular mechanisms of immune-mediated disorders including infectious and autoimmune diseases.
Secondary Appointments: Cell Biology and Biochemistry Genetic disorders of B cell development in the human.
Secondary Appointments: Molecular pathogenesis of group A streptococcal infections; Development and design of group A streptococcal vaccines.
Role of IFN-gamma in the formation and maintenance of granulomas in the lung following infection or exposure to particulate matter.
Secondary Appointments: Regulation of T-cell responses in and immunotherapy for autoimmune diseases.
Secondary Appointments:
Secondary Appointments:
Secondary Appointments:
Secondary Appointment: Molecular Therapeutics and Cell Signaling NK cell and stem cell transplantation; Late effect and molecular epidemiology.
Secondary Appointment: Molecular Therapeutics and Cell Signaling Virus-host cell interactions during infections of hepatitis C virus and related viruses; innate immune signaling mechanisms to viral infections. Tony Marion, Ph.D., Professor, Dept. of Molecular Sciences, tmarion@uthsc.edu Secondary Appointments:
Jonathan A. McCullers,
M.D., Assistant Member, Department of Infectious Diseases, St. Jude Children’s Research Hospital, jon.mccullers@stjude.org My lab works on the mechanisms and virulence factors underlying the interaction between respiratory viruses and bacteria. Current research is focusing on influenza viruses, Streptococcus pneumoniae and staphylococcus. Mark Miller,
Ph.D., Associate Professor, Dept. of Molecular Sciences, mamiller@uthsc.edu Development of vectors for delivery of cytokine-assisted vaccines focusing on the use of replication-defective vesicular stomatitis virus as a delivery vector for cytokine-adjuvant(s) in combination with either exogenous or virus-encoded candidate immunogens.
Secondary Appointments: Regulation of the innate immune response.
Secondary Appointments: Genetics, Functional Genomics and Proteomics Molecular determinants of host range and pathogenesis and vaccine development.
Secondary Appointments: Cell Biology and Biochemistry Molecular analysis of autoantibody structure and characterization of autoantigens that elicit autoimmune responses.
Secondary Appointment: Molecular Therapeutics and Cell Signalling Recognition of microbial products by Toll-like receptors; Cytokine induction in dendritic cells and macrophages.
Secondary Appointment: Genetics, Functional Genomics, and Proteomics Antifungal action and resistance in the pathogenic fungi Candida albicans and Candida glabrata; Host innate immune response to Candida albicans and Candida glabrata.
Secondary Appointments: Role of the MHC class II molecules, T cells, and cytokines in susceptibility to autoimmune arthritis.
Charles J. Russell, Ph.D., Assistant Member, Department of Infectious Diseases, St. Jude Children’s Research Hospital, charles.russell@stjude.org Secondary Appointment: Molecular Therapeutics, Drug Development and
Cell Signaling Molecular mechanisms of paramyxovirus entry and pathogenesis; development of vaccines against paramyxovirus infection; structure-based design of inhibitors against paramyxovirus replication.
Secondary Appointments:
Secondary Appointments: Molecular mechanisms of pneumococcal invasion using in vivo and in vitro
models of pneumonia, sepsis, and meningitis. Richard Webby, Ph.D., Assistant Member, Dept. of Infectious Diseases, richard.webby@stjude.org Secondard Appointment: Genetics, Functional Genomics, Immunology, and
Inflammation Reverse genetics technologies to improve influenza vaccines, as well as to understand the pathogenesis of, and immune response to, influenza viruses
Secondary Appointments: Michael Whitt, Ph.D., Professor, Dept. of Molecular Sciences, mwhitt@uthsc.edu Secondary Appointments: Cancer and Developmental Biology Molecular basis of negative-strand virus entry, replication, and assembly; Development of cell-specific cytolytic and oncolytic vectors; Molecular mechanisms of viral oncolysis with emphasis on glioblastoma multiformae. Revised 18 August 2008
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