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College of Graduate Health Sciences

Integrated Program in Biomedical Sciences

Cell Biology and Biochemistry

John Cox, Ph.D., Associate Professor, Dept. of Molecular Sciences, jcox@uthsc.edu

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: 117, 119 Molecular Sciences Building

Regulation of the endocytosis and intracellular trafficking of membrane
transporters, and the role of the cytoskeleton in these processes.


John Fain, Ph.D., Van Vleet Professor, Dept. of Molecular Sciences, jfain@uthsc.edu

Secondary Appointments: Molecular Therapeutics and Cell Signaling
Laboratory Location: 512 Molecular Sciences Building

Adipokine release by adipose tissue from obese humans.


Zheng Fan, Ph.D., Associate Professor, Dept. of Physiology, zfan@physio1.uthsc.edu

Secondary Appointments: Genetics, Functional Genomics and Proteomics
Laboratory Location: 550, 551, 354 Nash Building

Molecular structure and physiological function of ion channels.


Linda Hendershot, Ph.D., Member, Dept. of Genetics/Tumor Cell Biology, Linda.hendershot@stjude.org

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: 5002 Danny Thomas Research Tower, St. Jude

Biosynthesis of proteins in the secretory pathway; Signal transduction pathways that are activated by cellular stress.


Polly Hofmann, Ph..D., Associate Professor, Dept. of Physiology, phofmann@physio1.uthsc.edu

Secondary Appointments: Molecular, Cellular, and Systems Physiology
Laboratory Location: 350 Nash Annex

Second messenger signalling pathways in the heart.


Roderick Hori, Ph.D., Associate Professor, Dept. of Molecular Sciences, rhori@uthsc.edu

Secondary Appointments: Genetics, Functional Genomics and Proteomics
Laboratory Location: 315 Molecular Sciences Building

Mechanism of eukaryotic transcriptional regulation.


James Ihle, Ph.D., Member, Dept. of Biochemistry, james.ihle@stjude.org

Secondary Appointments: Molecular Therapeutics and Cell Signaling
Laboratory Location: MC 340 Danny Thomas Research Tower, St. Jude

Biochemical pathways in cytokine receptor signal transduction; Roles of the Jak family of kinases and the Stat family of transcription factors.


Suzanne Jackowski, Ph.D., Member, Dept. of Infectious Disease, Suzanne.jackowski@stjude.org

Secondary Appointments: Microbial Pathogenesis, Immunology and Inflammation
Laboratory Location: E8019 Integrated Research Center, St. Jude

Roles of phospholipid synthesis in cellular functions; Regulation of coenzyme A as a determinant of metabolic switching.


Lisa Jennings, Ph.D., Professor and Director, Dept. of Medicine-Internal Medicine, ljennings@uthsc.edu

Secondary Appointments: N/A
Laboratory Location: H300 Coleman Building

The molecular basis of cell adhesion and cell growth facilitated by cell surface integrins and tetraspanins

Leonard Johnson, Ph.D., Thomas A. Gerwin Professor and Chair, Dept. of Physiology, ljohn@physio1.uthsc.edu

Secondary Appointments: Molecular, Cellular, and Systems Physiology
Laboratory Location: 554 Nash Annex

The role of polyamines in growth and migration of intestinal epithelial cells.



Seema Khurana, Ph.D., Associate Professor, Dept. of Physiology, skhurana@uthsc.edu

Secondary Appointment: Molecular Therapeutics and Cell Signaling
Laboratory Location: 414, 416, 418 Nash Building

Moving cells, their mechanics and actin dynamics.

Abbas Kitabchi, M.D., Ph.D., Professor, Dept. of Medicine, akitabchi@uthsc.edu

Secondary Appointments: Molecular, Cellular, and Systems Physiology
Laboratory Location: 329M Dobbs Building

Role of hyperglycemia on oxidative stress and signal transduction in T lymphocytes.


Katsumi Kitagawa, Ph.D., Assistant Member, Dept. of Molecular Pharmacology, katsumi.kitagawa@stjude.org

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: D3012 Danny Thomas Research Center, St. Jude

Kinetochore and cell cycle progression.


Anjaparavanda Naren, Ph.D., Assistant Professor, Dept. of Physiology, anaren@physio1.uthsc.edu

Secondary Appointment: Molecular, Cellular, and Systems Physiology
Laboratory Location: 415 Nash Building

Protein-protein interactions that regulate Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function.


Ken Nishimoto, Ph.D., Professor, Dept. of Molecular Sciences, snishimoto@uthsc.edu

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: 311 Molecular Sciences Building

Bone formation, calcification and mechanisms to regulate bone mass.


Janet Partridge, Ph.D., Assistant Member, Department of Biochemistry, St. Jude Children’s Research Hospital, janet.partridge@stjude.org

Secondary Appointment: Cancer and Developmental Biology
Laboratory Location: D-4063F – Mail Stop 340, St. Jude Children’s Research Hospital

Contribution of the RNAi pathway in promoting genomic stability by establishing and propagating centromeric heterochromatin.


Tayebeh Pourmotabbed, Ph.D., Associate Professor, Dept. of Molecular Sciences, tpourmotabbe@uthsc.edu

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: 421, 423 Molecular Sciences Building

Role of matrix metalloproteinases in glioma and arthritis; Targeting glioma by anti-MMP inhibitors.


Gadiparthi Rao, Ph.D., Associate Professor, Dept. of Physiology, grao@physio1.uthsc.edu

Secondary Appointments: Molecular, Cellular, and Systems Physiology
Laboratory Location: 460 Nash Building

Role of eicosanoids in vessel wall remodeling; Role of NFATs in vessel wall remodeling.


Radhakrishna Rao, Ph.D., Associate Professor, Dept. of Physiology, rkrao@physio1.uthsc.edu

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location: 520 Nash Building

Regulation of epithelial tight junctions by signal transduction and cytoskeleton.


John Schuetz, Ph.D., Vice Chair, Dept. of Pharmaceutical Sciences, St. Jude Children’s Hospital, john.schuetz@stjude.org

Secondary Appointment:  Molecular, Cellular  and Systems Physiology
            Laboratory Location: Room I5207 Chili Care Center, St. Jude

Role of ABC transporters in response to chemotherapy, Biological function of ABC transporters and Regulation of ABC transporters

Brenda Schulman, Ph.D., Assistant Member, Dept. of Structural Biology and Genetics/Tumor Cell Biology, brenda.schulman@stjude.org

Secondary Appointment: Genetics, Functioanl Genomics, and Proteomics
Laboratory Location: Room D5063, Danny Thomas Research Tower, St. Jude

Molecular basis for posttranslational modification by ubiquitin and ubiquitin-like proteins.


Susan Senogles, Ph.D., Associate Professor, Dept. of Molecular Sciences, ssenogles@uthsc.edu

Secondary Appointments: Neuroscience
Laboratory Location: 321, 323 Molecular Sciences Building

Molecular determinants of D2 Dopamine Receptor/G protein specificity.


Charles Sherr, M.D., Ph.D., Member, Dept. of Genetics/Tumor Cell Biology, charles.sherr@stjude.org

Secondary Appointments: Cancer Biology and Developmental Biology
Laboratory Location:

Solomon Solomon, M.D., Professor, Dept. of Medicine, ssolomon@uthsc.edu

Secondary Appointments: Genetics, Functional Genomics and Proteomics
Laboratory Location: BE 117, 120, 122 Veterans Affairs Medical Center,

Pathogenessis of diabetic ketoacidosis; Mechanisms of insulin action in reversing the DKA.


Dario Vignali, Ph.D., Associate Member, Dept. of Immunology, Dario.vignali@stjude.org

Secondary Appointments: Microbial Pathogenesis, Immunology and Inflammation
Laboratory Location: E-7054, 7076 Integrated Research Center, St. Jude

TCR:CD3 cell biology, signal transduction and function; Regulation of T cell function and homeostasis; T cell specificity and function in type 1 diabetes.


Stephen White, D.Phil., Member and Chair, Dept. of Structural Biology, Stephen.white@stjude.org

Secondary Appointments: Genetics, Functional Genomics and Proteomics
Laboratory Location: D1024E, Danny Thomas Research Tower, St. Jude

Structural studies by X-ray crystallography on biological macromolecules with emphasis on fatty acid synthesis, protein-DNA and protein-RNA interactions, and structure-assisted drug design


Jie Zheng, Ph.D., Assistant Member, Dept. of Structural Biology, jie.zheng@stjude.org

Secondary Appointments: Molecular Therapeutics and Cell Signaling
Laboratory Location: MS 311,D1024-B, Danny Thomas Research Center, St. Jude

Structural biology of the Wnt signaling pathway; Molecular basis of focal adhesion kinase.

Revised 18 August 2008