Molecular Sciences

Spring 2008

Fall 2008

MSCI 612	Elements of Microbiology	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: 5
A course on the fundamental aspects of microbial growth, nutrition, and genetics; mechanisms of infection and resistance; and a survey of disease-producing microorganisms with emphasis on those associated with the oral cavity. Dental student course.

MSCI 621

Medical Microbiology and Immunology

Pat Ryan

Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester

Day : TTh Time : 10-11:50 Place : GEB A103

Credit: 6

An intensive basic lecture course on the principles and concepts of microbiology and immunology, including microbial physiology and metabolism, genetics and gene regulation, mechanisms of humoral and cell-mediated immunity, animal virology, mechanisms of resistance to infection, and the specific role of microbial agents in disease. Medical student course.

MSCI 800	Master's Thesis and Research	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: by arrangement
Research performed under the direction and supervision of the respective student's advisor, in partial fulfillment of the requirements for the degree of Master of Science

MSCI 828	Principles of Laboratory Instruction	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: 3
Conferences on methods of instruction and practice in supervision of students who are performing laboratory experiments.

MSCI 900	Doctoral Dissertation and Research	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: and hours by arrangement
Research performed under the direction and supervision of the respective student's advisor, in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

MSCI 910

Student Seminar

Pat Ryan

Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester

Day : Tu Time : 12-1:30 Place : GEB A302

Credit: 3

Reports of current research are made by students for fellows and staff. Presentations are followed by general informal discussion. Under certain circumstances, topics of current interest in the field are selected and reviewed by students and staff members.

MSCI 932

Viral Pathogenesis

Michael Whitt

Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester

Day : TBA Time : TBA Place : TBA

Credit: 2

The goal of this course is to explore the interactions between viruses and their hosts that result in pathogenic effects and disease. The course will provide an understanding of virus structure, entry, replication and assembly which will form the basis for a comprehensive overview of the molecular and cellular mechanisms responsible for pathogenesis resulting from infection of a host by viruses. The first portion of the course consists of lectures and discussion that present in detail the molecular, structural, and cellular mechanisms that determine virus tropism, entry, replication, dissemination, and responses by the host. The second half of the course will build on information presented in MSCI 931 ?Immune Response to Pathogens? using defined virus model systems to provide a comprehensive and fundamental understanding of the concepts that govern virus-host interactions and that lead to disease. Upon completion of the course, students will have a comprehensive understanding of the molecular and cellular bases for pathogenesis resulting from infection of a host by viruses. The topics are discussed using a format involving a series of introductory lectures followed by a second series of classes consisting of in-class discussion of pertinent research papers. The papers to be read and discussed include classical papers establishing essential concepts and current papers that add detail to the topic under discussion.

MSCI 933

Molecular Basis of Bacterial Pathogenesis

David Hasty

Starting date (MM/dd/yyyy) : 10/15/2007 Ending date (MM/dd/yyyy) : End of semester

Day : MWF Time : 9-10:20 Place : GEB A310

Credit: 2

The course will provide a comprehensive overview of bacterial pathogenesis from the perspective of both host and pathogen. The lectures are intended to complement the immunology and pathophysiology lectures in IP842 "Systems Biology" and MSCI931 "Immune Response to Pathogens" to provide a comprehensive and fundamental understanding of the concepts that govern host-pathogen interactions. Lectures will present in detail the molecular genetic, structural, and cellular mechanisms that bacterial pathogens use to infect cells and tissues of the host and the subsequent disease consequences of infection. Prerequisite: IP842 Systems Biology, IP843 Cellular and Molecular Biology, and MSCI Immune Response to Pathogens, or permission of the course director. Fall, 2 credits (2-0). At the end of the course, students will have a comprehensive understanding of bacterial virulence and pathogenesis. Students will understand in detail the molecular genetic, structural, and cellular basis for bacterial pathogenesis. Students will gain a comprehensive understanding of virulence factors, how their expression is controlled at both the molecular and cellular levels and how these bacterial factors affect cells and tissues of the host. Combined with the information learned in the prerequisite courses, students will also have a comprehensive understanding of host-pathogen relationships that ultimately lead to the elimination of infectious agents or the establishment of productive infections.

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Molecular Sciences program page

Spring 2008

MSCI 612	Elements of Microbiology	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day : TBA Time : TBA Place : GEB A102		Credit: 5
A course on the fundamental aspects of microbial growth, nutrition, and genetics; mechanisms of infection and resistance; and a survey of disease-producing microorganisms with emphasis on those associated with the oral cavity. Dental student course.

MSCI 800	Master's Thesis and Research	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: by arrangement
Research performed under the direction and supervision of the respective student's advisor, in partial fulfillment of the requirements for the degree of Master of Science

MSCI 814	Bioinformatics I	David Nelson
Starting date (MM/dd/yyyy) : 01/10/2008 Ending date (MM/dd/yyyy) : 03/13/2008
Day : Th Time : 2:30-4:50 Place : GEB B107		Credit: 2
This course consists of eleven 2.5-hour segments. The material will be introduced in a brief lecture format for 30-45 minutes as necessary. The majority of time will be spent using computer applications of bioinformatics tools. The course is designed to provide practical training in bioinformatics methods including accessing the major public sequence databases, using the five BLAST tools to find sequences, analyzing protein and nucleic acid sequences, detecting motifs or domains in proteins, assembling protein sequences from genomic DNA, detecting exons and finding intron-exon boundaries, aligning sequences (Clustal W), and making phylogenetic trees (Phylip). Basic proteomics methods and comparative genomics will also be discussed. Students should leave the course with a working knowledge of how to carry out research using these tools.

MSCI 815	Bioinformatics II	David Nelson
Starting date (MM/dd/yyyy) : 03/27/2008 Ending date (MM/dd/yyyy) : End of semester
Day : Th Time : 2:30-4:50 Place : GEB B107		Credit: 1
This course consists of six 2.5-hour segments partially as lecture and partially as computer tutorial sessions to demonstrate advanced bioinformatics methods and the use of databases. The course follows Bioinformatics I. Topics include knowledge base mining; 3D structure viewers like Cn3D, the VAST databases of 3D structure alignments; use of genome browsers like UCSC and Ensembl and NCBI's genomic biology section; gene arrays--their construction, use, and data analysis; mapping quantitative trait loci (QTLs) and radiation hybrid mapping; genome assembly and annotation.

MSCI 828	Principles of Laboratory Instruction	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: 3
Conferences on methods of instruction and practice in supervision of students who are performing laboratory experiments.

MSCI 861	Cellular Signaling	Susan Senogles
Starting date (MM/dd/yyyy) : 03/03/2008 Ending date (MM/dd/yyyy) : End of semester
Day : MWF Time : 9-10:20 Place : GEB A315		Credit: 3
The course will provide a comprehensive survey of cellular signaling, describing, mechanisms of signal transduction. The lectures will detail cellular signaling from the major classes of cell surface receptors to the impact on nuclear events. The class will emphasize the integration and coordination of signaling pathways in the cell and how this impacts on the fact of the cell. Prerequisite(s): IP 842 Systems Biology , IP 843 Cellular and Molecular Biology

MSCI 900	Doctoral Dissertation and Research	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day: TBA Time: TBA Place: TBA		Credit: and hours by arrangement
Research performed under the direction and supervision of the respective student's advisor, in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

MSCI 910	Student Seminar	Pat Ryan
Starting date (MM/dd/yyyy) : Start of semester Ending date (MM/dd/yyyy) : End of semester
Day : TBA Time : 12-12:50 Place : GEB A302		Credit: 3
Reports of current research are made by students for fellows and staff. Presentations are followed by general informal discussion. Under certain circumstances, topics of current interest in the field are selected and reviewed by students and staff members.

MSCI 911	Applied Proteomics	George Hilliard
Starting date (MM/dd/yyyy) : 01/08/2008 Ending date (MM/dd/yyyy) : 04/29/2008
Day : Tu Time : 9-10:50 Place : GEB A313		Credit: 2
The goal of this course will be to systematically evaluate the use of proteomics in defined experimental situations. In the first part of the course this will be accomplished by requiring students to read and present relevant articles from the proteomic literature to learn the strengths and weaknesses of different proteomic approaches. Subsequently, direct perspective of the practicality/efficiency of these approaches will be gained by applying proteomics to research projects of each student followed by class presentation, discussion, and analysis of real proteomics data and results. These research projects may be actual components of the graduate research project, or hypothetical, correct application of current methods relevant to the students' graduate work or special interest.

MSCI 928	Principles of Mass Spectrometry	Sarka Beranova
Starting date (MM/dd/yyyy) : 01/09/2008 Ending date (MM/dd/yyyy) : 05/07/2008
Day : W Time : 1-2:50 Place : TBA		Credit: 2
A course on the state-of-the-art techniques in the field of mass spectrometry offered in alternate years.

MSCI 929	Techniques in Molecular Biology	Martha Howe
Starting date (MM/dd/yyyy) : 03/03/2008 Ending date (MM/dd/yyyy) : End of semester
Day : MTuWThF Time : 10:30-11:50 Place : GEB A315		Credit: 4
The theory and practical application of commonly used laboratory techniques in molecular biology, biochemistry, cell biology, immunology, and structural biology are considered, including hybridization and microarray technology; PCR; recombinant DNA enzymes, vectors and clone detection methods; transgenic mouse technology; in vitro mutagenesis and footprinting; multiple chromatographic methods for use both with and without tags; protein purification strategies; electrophoresis and blotting; mass spectroscopy and proteomics; NMR and X-ray crystallography; generation and uses of monoclonal antibodies; flow cytometry; light and fluorescence microscopy; and cell purification.

MSCI 931	Immunity and Inflammation	Tony Marion
Starting date (MM/dd/yyyy) : 03/04/2008 Ending date (MM/dd/yyyy) : End of semester
Day : TuTH Time : 9-10:20 Place : GEB A315		Credit: 2
The course will provide a comprehensive overview of resistance to infection and immunity to viral and bacterial pathogens. The lectures are intended to complement the immunology and pathophysiology lectures in IP 842 Systems Biology to provide a comprehensive and fundamental understanding of the concepts that govern host-pathogen interactions. Lectures will present in detail the molecular genetic, structural, and cellular mechanisms that determine innate and adaptive immune cell activation and effector function. The literature review will use landmark papers to document research that has elucidated innate and adaptive immune mechanisms that determine resistance to infection by bacteria and viruses. At the end of the course, students will have a comprehensive understanding of innate and adaptive immunity to viruses and bacteria. Students will understand in detail the molecular genetic, structural, and cellular basis for immune response to viruses and bacteria. Combined with the information learned in Molecular and Cellular Bases for Pathogenesis of Viruses? and ?Molecular and Cellular Bases for Pathogenesis of Bacteria, students will have a comprehensive understanding of host-pathogen relationships that ultimately lead to the elimination of infectious agents or the establishment of productive infections. Prerequisite(s): IP 842 Systems Biology

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Molecular Sciences program page

last update 2008-05-29 14:10 local time





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