Division Faculty

Charles M. Mansbach, II, M. D.

Professor of Medicine and Physiology
Basic Science Investigator

Research

The Mansbach Laboratory

Medical School

New York University, New York, NY, 1963

Residency

Duke University, Durham, NC

Fellowship

Gastroenterology, Duke University, Durham, NC

Board Certifications

American Board of Internal Medicine
American Board of Internal Medicine, Gastroenterology

Clinical Interests

Diarrhea and Malabsorption

Research Interests

Lipid metabolism and intracellular transport of triglycerides through intestinal absorptive cells.

Selected Publications

1. Siddiqi, S; Mansbach C.M. PKC Mediated Phosphorylation Controls Budding of the Pre-Chylomicron Transport Vesicle, Journal of Cell Science, In press, 2008
2. Neeli, I, Siddiqi, S.A., Siddiqi, S., Lagakos, W.S., Binas,B. Gheyi, T. Storch, J, Mansbach, C.M., II. Liver fatty acid binding protein initiates budding of pre-chylomicron transport vesicles from intestinal endoplasmic reticulum. J Biol Chem 282:17974-84, 2007
3. Lu, S., Yao, Y., Cheng, X,, Mitchell, S., Meng, S., Gallagher, J.W., Shelness, G.S., Morris, G.S., Mahan, J., Frase, S., Mansbach, C.M., II, Weinberg, R.B., Black, D.D. Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. J Biol Chem 281(6):3473-4383, 2006.
4. Siddiqi, S.A., Mahan, J., Siddiqi, S., Gorelick, F.S., and Mansbach, Charles M., II. Vesicle associated membrane Protein7 is expressed in intestinal ER. J Cell Sci 119 (Pt. 5):943-950, 2006.
5. Maroney, S.A., Cunningham, A.C., Ferrel, J., Hu, R., Haberichter, S., Mansbach, C.M., Brodsky, R.A., Dietzen, D.J., Mast, A.E. A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression. J Thrombosis Haemostasis 4; 1114 – 1124, 2006.
6. Siddiqi, S.A., Siddiqi, S., Mahan, J., Peggs, K., Gorelick, F.S., and Mansbach, C.M., II . The Identification of a novel ER to Golgi SNARE complex used by the Pre-chylomicron Transport Vesicle. J Biol Chem 281: 20974-20982, 2006.
7. Siddiqi, S.A., Gorelick, F.S., Mahan, J., and Mansbach, C.M: 2003. COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre chylomicron transport vesicle. J Cell Sci 116:415-427.
8. Washington, L., Cook, G.A., and Mansbach, C.M. II: 2003. Inhibition of carnitine palmitoyltransferase-I in the rat small intestine inhibits export of triacylglycerol to the lymph. J. Lipid Res. 44:1395-1403.
9. Mahan, J.T., Heda, G.D., Rao, R.H., and Mansbach, C.M. II. 2001. The intestine expresses pancreatic triacylglycerol lipase: regulation by dietary lipid. Am J Physiol 280:G1187-G1196.
10. Mansbach CM, Dowell R. 2000. Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi. J Lipid Res. 41(4): 605-12.
11. Kumar NS, Mansbach CM. 1999. Prechylomicron transport vesicle: isolation and partial characterization. Am J Physiol. 276(2 Pt 1): G378-86.

Contact Us

Division of Gastroenterology and Hepatology
956 Court Ave, Suite H210
Memphis, TN 38163
Phone: 901-448-5813
Fax: 901-448-7091
Site contact: Lisa Jones

A division of the
Department of Internal Medicine