Division Faculty

Charles M. Mansbach, II, M. D.
Professor of Medicine and Physiology
Basic Science Investigator

Medical School:

New York University, New York, NY, 1963

Residency:

Duke University, Durham, NC

Fellowship:

Gastroenterology, Duke Univeristy, Durham, NC

Board Certifications:

American Board of Internal Medicine

American Board of Internal Medicine, Gastroenterology

Clinical Interests: Diarrhea and Malabsorption

Research Interests:  Lipid metabolism and intracellular transport of triglycerides through intestinal absorptive cells.

Dr. Mansbach's Lab

Selected Publications:

1. Neeli, I, Siddiqi, S.A., Siddiqi, S., Lagakos, W.S., Binas,B. Gheyi, T. Storch, J, Mansbach, C.M., II. Liver fatty acid binding protein initiates budding of pre-chylomicron transport vesicles from intestinal endoplasmic reticulum. J Biol Chem 282:17974-84, 2007

2. Lu, S., Yao, Y., Cheng, X,, Mitchell, S., Meng, S., Gallagher, J.W., Shelness, G.S., Morris, G.S., Mahan, J., Frase, S., Mansbach, C.M., II, Weinberg, R.B., Black, D.D. Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. J Biol Chem 281(6):3473-4383, 2006.

3. Siddiqi, S.A., Mahan, J., Siddiqi, S., Gorelick, F.S., and Mansbach, Charles M., II. Vesicle associated membrane Protein7 is expressed in intestinal ER. J Cell Sci 119 (Pt. 5):943-950, 2006.

4. Maroney, S.A., Cunningham, A.C., Ferrel, J., Hu, R., Haberichter, S., Mansbach, C.M., Brodsky, R.A., Dietzen, D.J., Mast, A.E. A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression. J Thrombosis Haemostasis 4; 1114 – 1124, 2006.

5. Siddiqi, S.A., Siddiqi, S., Mahan, J., Peggs, K., Gorelick, F.S., and Mansbach, C.M., II . The Identification of a novel ER to Golgi SNARE complex used by the Pre-chylomicron Transport Vesicle. J Biol Chem 281: 20974-20982, 2006 .

6. Siddiqi, S.A., Gorelick, F.S., Mahan, J., and Mansbach, C.M: 2003. COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre chylomicron transport vesicle. J Cell Sci 116:415-427.

7. Washington, L., Cook, G.A., and Mansbach, C.M. II: 2003. Inhibition of carnitine palmitoyltransferase-I in the rat small intestine inhibits export of triacylglycerol to the lymph. J. Lipid Res. 44:1395-1403.

8. Mahan, J.T., Heda, G.D., Rao, R.H., and Mansbach, C.M. II. 2001. The intestine expresses pancreatic triacylglycerol lipase: regulation by dietary lipid. Am J Physiol 280:G1187-G1196.

9. Mansbach CM, Dowell R. 2000. Effect of increasing lipid loads on the ability of the endoplasmic reticulum to transport lipid to the Golgi. J Lipid Res. 41(4): 605-12.

10. Kumar NS, Mansbach CM. 1999. Prechylomicron transport vesicle: isolation and partial characterization. Am J Physiol. 276(2 Pt 1): G378-86