Division Faculty

Thomas A. Hughes, M.D.

Professor of Medicine

Division of Endocrinology, Metabolism, and Diabetes

University of Tennessee, Health Science Center

920 Madison Ave., Room 326

Memphis, TN 38163  

Office Phone:   901-448-5744

Lab Phone:   901-448-4659

FAX:   901-448-5332

E-Mail:   thughes@utmem.edu              

         Thomas A. Hughes, M.D., is a Professor of Medicine at the University of Tennessee, Memphis.  He came to the University of Tennessee from the University of Alabama, Birmingham, in 1987 to participate in the Diabetes Control and Complications Trial (DCCT).  Dr. Hughes attended medical school at Washington University in St. Louis, where he received his M.D. degree in 1975.  He received his Endocrinology training at the University of North Carolina, Chapel Hill, and is board certified in General Internal Medicine and Endocrinology, Metabolism, and Diabetes.  Before leaving UAB, Dr. Hughes established the Lipid Metabolism Clinic at that institution.  Since coming to UT, he has participated in the UT Medical Group Lipid-Diabetes Clinics, as well as the Transplantation Clinic, and is the Medical Director of the Lipoprotein Composition Laboratory.  His primary research and clinical interest is in lipoprotein metabolism and atherosclerosis but also has interests in Diabetes Mellitus, Metabolic Bone Disease, obesity, and transplantation. 

PUBLICATIONS:

1.  Segrest JP, Chung BH, Cone JT, and Hughes TA: Coronary Heart Disease Risk Assessment by Plasma Lipoprotein Profiles.  Alabama Journal of Medical Sciences 20:76-82, 1983.

2.  Herbst CA, Hughes TA, Gwynne JT, Buckwalter JA: Gastric Bariatric Surgery in Insulin Treated Adults.  Surgery 95:(2) 209-213, 1984.

3.  Hughes TA, Gwynne JT, Switzer BR, Herbst C, White G: The Effects of Caloric Restriction and Weight Loss on Glycemic Control, Insulin Release and Resistance and Atherosclerotic Risk in Obese Patients with Type II Diabetes Mellitus.  American Journal of Medicine 77:7-17, 1984.

4.  Gwynne JT, Hughes TA, Hess B:  Characterization of HDL Binding Activity in Rat Adrenocortical Cells.  Journal of Lipid Research 25:1059-1071, 1984.

5.  Gwynne JT, Hess B, Hughes TA, Roundtree R, and Mahaffee D: The Role of Serum High Density Lipoproteins in Adrenal Steroidogenesis.  Endocrine Research 10:411-430, 1985.

6.  Anantharamaiah GM, Jones JL, Brouillette CG, Schmidt CF, Chung BH, Brown AS, Hughes TA, and Segrest JP: Studies of Synthetic Peptide Analogues of the Amphipathic Helix: Structure of Complexes with Demyristoyl Phosphatidylcholine.  Journal of Biological Chemistry 260:10248-10255, 1985.

7.  Hughes TA, Kramer JO, Segrest JP:  Effects of Glyburide Therapy on Lipoproteins in NIDDM.  American Journal of Medicine 79:(Suppl 3B) 86-91, 1985.

8.  Hughes TA, Clements RS, Fairclough PK, Bell DSH, Segrest JP:  Effect of Insulin Therapy on Lipoproteins in NIDDM.  Atherosclerosis 67:105-114, 1987.

9.  Hughes TA, Moore MA, Neame P, Medley MF, and Chung BS: Rapid  Quantitative Apolipoprotein Analysis by Gradient Ultracentrifugation and Reversed-phase HPLC.  J Lipid Research 29:363-376, 1988.

10.  Anantharamaiah GM, Hughes TA, Gawish A, Segrest JP, Neame PJ, Medley MF, Iqbal M:  Effect of Oxidation on the Properties of  Apolipoproteins A-I and A-II.  J Lipid Research 29:309-318, 1988.

11.  Hughes TA, Atchison J, Elliott SK, Hazelrig JB, Boshell BR:  Effect of Food Composition on Glycemic Responses in IDDM.  American Journal of Clinical Nutrition 49:658-666, 1989.

12.  Rumbak MJ, Hughes TA, Kitabchi AE: Pseudonormoglycemia in Diabetic Ketoacidosis with Elevated Triglycerides.  American Journal of Emergency Medicine 9:61-63, 1991.

13.  Hughes TA, Gaber AO, Montgomery CE:  Plasma Distribution of Cyclosporin within Lipoproteins and "In Vitro" Transfer Between VLDL, LDL, and HDL. Therapeutic Drug Monitoring 13:289-295, 1991.

14.  Hughes TA, Moore MA, Joyce M, Go RCP, Segrest JP, Blackwell T:  Sexual Differences in Lipoprotein Composition in a Family with Dyslipidemic Hypertension and Premature Atherosclerosis: Deficiency of HDL-L and HDL-M "apoA-I Alone" Particle".  Journal of Laboratory and Clinical Medicine 119:57-68, 1992.

15.  Hughes TA, Gaber AO, Amiri H, Kaminska E, Hathaway D, Winsett R, Elmer D, Wang X:  Lipoprotein Improvements with Pancreas-Renal Transplantation.  Transplantation Proceedings 24:840-841, 1992.

16.  Shokouh-Amiri MH, Gaber AO, Gaber LW, Jensen SL, Hughes TA, Elmer D, Britt L:  Pancreas Transplantation with Portal Venous Drainage and Enteric Exocrine Diversion: A New Technique.  Transplantation Proceedings 24:776-777, 1992.

17.  Gaber AO, Shokouh-Amiri MH, Hathaway DK, Elmer D, Kitabchi AE, Stentz F, Hughes TA:  Pancreas Transplantation with Portal Venous and Enteric Drainage Eliminates Hyperinsulinemia and Reduces Postoperative Complications.  Transplantation Proceedings 25:1176-1178, 1993.

18.  The Diabetes Control and Complications (DCCT) Research Group:  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.  N Engl J Med 329:977-986, 1993.

19.  Hughes TA, Gaber AO, Amiri HS, Wang X, Elmer DS, Winsett RP, Hathaway DK, Hughes SM, Ghawji M:  Lipoprotein Composition in Insulin-dependent Diabetes Mellitus with Chronic Renal Failure:  Effect of Kidney and Pancreas Transplantation.  Metabolism 43:333-347, 1994.

20.  Hughes TA, Gaber AO, Amiri HS, Wang X, Elmer DS, Winsett RP, Hathaway DK, Hughes SM, Ghawji M:  Lipoprotein Composition in Insulin-dependent Diabetes Mellitus with Chronic Renal Failure:  Effect of Kidney and Pancreas Transplantation.  Transplantation Proceedings 26:1, 1994.

21.  Elmer DS, Hathaway DK, Amiri HS, Hughes TA, Gaber LW, Gaber AO:  Glucose Disappearance Constant (kG) Provides an Alternative Diagnostic Marker of Acute Pancreas Allograft Rejection.  Transplantation Proceedings 26:536, 1994.

22.  Elmer DS, Hathaway DK, Amiri HS, Hughes TA, Gaber AO:  The Relationship of Glucose Disappearance Rate (kG) to Acute Pancreas Allograft Rejection.  Transplantation 57:1400-1405, 1994.

23.  Buffington CK, Cowan GSM, Jr., Hughes TA:  Significant changes in the lipid-lipoprotein status of premenopausal morbidly obese females following gastric bypass surgery.  Obesity Surgery 4:328-335, 1994.

24.  Insull W, Davidson MH, Demke DM, Dujovne CA, Eckert SM, Ginsberg D, Goldberg AC, Hodis HN, Hughes TA, Kane JP, Oliphant TH, Pitt WA, Schrott HG, Sprecher DL, Zavoral:  The effects of colestipol tablets compared with colestipol granules on plasma cholesterol and other lipids in moderately hypercholesterolemic patients.  Atherosclerosis 112:223-235, 1995.

25.  Hughes TA, Elam MB, Applegate WB, Bond MB, Hughes SM, Wang X, Tolley EA, Bittle JB, Stentz FB, Kang ES:  Postprandial Lipoprotein Responses in Hypertriglyceridemic Subjects with and without Cardiovascular Disease.  Metabolism 44:1082-1098, 1995.

26.  Hughes TA, Gaber AO, Amiri HS, Wang X, Elmer DS, Winsett RP, Hathaway DK, Hughes SM:  Kidney-Pancreas Transplantation: Effect of Portal versus Systemic Venous Drainage of the Pancreas on Lipoprotein Composition.  Transplantation 60:1406-1412, 1995.

27.  Elmer DS, Hughes TA, Hathaway DK, Shokouh-Amiri MH, Gaber LW, Nymann T, Gaber AO:  Use of Glucose Disappearance Rates to Monitor beta-Cell Function of Pancreas Allografts.  Transplantation Proceedings 27:2985-2986, 1995.

28.  The Diabetes Control and Complications (DCCT) Research Group.  Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial.  Kidney Int 47:1703-20, 1995.

29.  The Diabetes Control and Complications (DCCT) Research Group.  Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications Trial.

Am J Cardiol 75:894-903, 1995.

30.  The Diabetes Control and Complications (DCCT) Research Group.  Progression of retinopathy with intensive versus conventional treatment in the Diabetes Control and Complications Trial.  Ophthalmology 102:647-661, 1995.

31.  Hughes TA, Heimberg M, Wang X, Wilcox H, Hughes SM, Tolley EA, Desiderio DM:  Comparative Lipoprotein Metabolism of Myristate, Palmitate, and Stearate in Normolipidemic Men.  Metabolism 45:1108-1118, 1996.

32.  Kang ES, Acchiardo SR, Wang YB, Hughes TA, Cardosa S:  Hypotension during hemodialysis: Role for nitric oxide.  Amer J Med Sciences 313:138-146, 1997.

33.  Elmer DS, Hathaway DK, Bashar Abdulkarim A, Hughes TA, H Shokouh-Amiri, Gaber LW, Gaber AO:  Use of glucose disappearance rates (kG) to monitor endocrine function of pancreas allografts.  Clin Transplantation 12:56-64, 1998.

34.  Kritchevsky D, Tepper SA, Wright S, Kuksis A, Hughes TA:  Cholesterol Vehicle in Experimental Atherosclerosis. 20. Cottonseed Oil and Randomized Cottonseed Oil.  Nutrition Research 18:259-264, 1998.

35.  Hughes TA, Pace DT, Ke RW, Tolley EA, Stentz F, Qureshi MN: Lipoprotein Compositional Changes with HRT (Conjugated Estrogen and Medroxyprogesterone) in African-American Women.  Endocrine Practice 10:179-186, May/June, 2004.

36.  Hughes TA, Stentz, F, Gettys T, Smith SR: Effect of Combining beta-Adrenergic and PPAR-gamma Stimulation on Lipoprotein Composition in Healthy, Moderately Obese Subjects.  Metabolism 55:26-34, 2006

37.  Carbone LD, Rosenberg EW, Tolley EA, Holick MF, Hughes TA, Watsky MA, Barrow KD, Chen TC,  Wilkin NK, Bhattacharya SK, Ahokas RA, Dowdy JC, Sayre RM, Weber KT: Effects of Controlled Ultraviolet Exposure on Cardiovascular and Skeletal Parameters.  Submitted 2007

38.  Elam MB, Cowan GS, Hiler ML, Raghow R, Park EA, Gerling IC, Patel D, Rooney RJ, Corton C, Cagen L, Wilcox H, Yellaturu C,  Deng X, Gandhi M, Bahr M, Allan C, Wodi L , Cook G, Hughes TA:

Altered Hepatic Gene Expression in Morbidly Obese Women and its Implications for Susceptibility to other diseases.  Submitted 2007

BOOK CHAPTERS:

1.  Gwynne JT, Hess B, Hughes TA, Holland S, Roundtree R, Mahaffee D, Irsula O, Reynolds J:  The "HDL Pathway" in the Rat Adrenal Cortex.  In Lipoprotein and Cholesterol Metabolism in Steroidogenic Tissues, (ed. Strauss and Menon), publisher: J.F. Stickley Co., Phil. PA., 1985.  

2.  Chung BH, Segrest JP, Ray MJ, Brunzell JD, Hokanson JE, Krauss RM, Hughes TA, Beaudrie K, Cone JT, Moore MA:  Single Vertical Spin Density Gradient Ultracentrifugation.  In Methods of Enzymology (Segrest JP and Albers JJ, eds.) Orlando, FL, Academic Press, Inc., 181-209, 1986.  

3.  Kritchevsky SB, Hughes TA, Belcher J, Gross M:  Carotenoid and Lipid/Lipoprotein Correlates of the Susceptibility of Low-density Lipoprotein to Oxidation in Humans.  In Antioxidants in Human Health  (eds. TK Basu, NJ Temple, ML Garg) CAB International, 1999. 

4.  Hughes TA:  Lipid Disorders.  In Obstetrics and Gynecology: Principles for Practice.  (eds. Ling FW and Duff P) Stamford, CT, Appleton & Lange, 636-651, 2001.