The University of Tennessee Health Science Center - Department of Comparative Medicine

Tumor Induction

Induction of neoplasia in laboratory animals by passage of live tumor cells or by exposure to carcinogens, requires careful observation of the animals for secondary effects of neoplasia. Animals found in a moribund state from tumor growth should be humanely euthanzed. Tumors passaged subcutaneously should be repassaged before they ulcerate through the skin. Tumors inoculated in rodents should be tested for presence of murine viruses to assure that they are not an infectious risk to other rodents being used in the animal facility.