| Publications :: | Professor
of Pediatrics Fellowship Program Director Division Chief, Pediatric Nephrology 
Since 1980 the focus of Dr. Wyatt’s research has been IgA nephropathy.
This disease is the most commonly occurring type of chronic kidney
inflammation and can occur in both children and adults. At least
20% of those identified with the disease will eventually progress
to end stage renal disease (need for dialysis or transplantation).
He has followed over 75 patients with this disease who were diagnosed
during childhood at Le Bonheur Children’s Medical Center and
over 60 diagnosed at the University of Kentucky Medical Center in
Lexington, Kentucky. This represents the largest group of pediatric
patients identified and followed by one investigator in North America.
Dr. Wyatt has been the first author on more articles related to IgA
nephropathy than anyone else in North America. Dr. Wyatt is also Assistant Director of the
University of Tennessee General Clinical Research Center that maintains
pediatric beds in the Le Bonheur Children’s Medical Center. As
Director of Research for Le Bonheur Children’s Medical Center,
Dr. Wyatt chairs the Research Committee that reviews all research
protocols that involve human subjects at the Le Bonheur Children’s
Medical Center. The Research Committee also administers the Le Bonheur
Small Grant program that provides $100,000 per year in grant support
to Le Bonheur-based investigators. Each year much of these funds are
awarded to investigators in the CFRC. |
Wyatt RJ, Lau KK, Novak J, Gaber LW. IgA Nephropathy and Henoch-Schönlein Purpura Nephritis. In: Kerr K, Makker SP, Schnapper HM (eds) Clinical Pediatric Nephrology, Taylor and Francis Medical Books, London, England (in press) Lau KK, Wyatt RJ, Gaber LW: Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis 2005; 46:1140-1144 Hogg RJ, Lee J, Nardelli N, Julian BA, Cattran D, Waldo B, Wyatt RJ, Jennette C, Sibley R, Hyland K, Fitzgibbons L, Hirschman G, Donadio J, Holub BJ. Placebo-controlled clinical trial evaluating omega-3 fatty acids and alternated day prednisone in patients with IgA nephropathy. Clin J Amer Soc Nephrol 2006; 1:467-474 Hastings MC, Wyatt RJ, Jones DP, Lau KK, Powell SL, Hayes DW, Gaber LW, Gaber AO, Ault BH. Five years' experience with Thymoglobulin induction in a pediatric renal transplant population. Pediatr Transplant, 2006, Nov: 10 (7):805-810McGlothan KR, Wyatt RJ, Ault BH, Hastings MC, Rogers T, DiSessa T, Jones DP. Predominance of nocturnal hypertension in pediatric renal allograft recipients. Pediatr Transplant 2006 2006 Aug; 10 (5):558-564 Lau KK, Hastings MC, Arnold SL, Jones DP, Boulden T, Shokouh-Amiri H, Wyatt RJ, Ault BH: Bartonella infection presenting with prolonged fever in a pediatric renal transplant recipient. Intl J Infect Dis 2006 Dec;10 (8):914-919 Lau KK, Delos Santos NM, Hastings MC, Ault BH, Jones DP, Roy III S, Wyatt RJ. Tularemia infection in a pediatric patient with chronic renal insufficiency and inguinal lymphadenopathy. Infec Dis Clin Practice (accepted for publication) Schachter AD, Benfield MR, Wyatt RJ, Grimm PC, Fennell RS, Herrin JT, Lirenman DS, McDonald RA, Munoz-Arizpe R, Harmon WE. Sirolimus pharmacokinetics in pediatric renal transplant recipients receiving calcineurin inhibitor co-therapy. Pediatr Transplant (accepted for publication) Novak J, Tomana M, Kafkova L, Matousovic K, Brown R, Hall S, Moldoveanu Z, Vu HL, Novak L, Novak Z, Mayne R, Julian BA, Mestecky J, Wyatt RJ. Activation of mesangial cells by IgA1 immune complexes from pediatric patients with IgA nephropathy. Pediatr Nephrol (under revision) Moldoveanu Z, Wyatt RJ, Lee J, Tomana M, Julian BA, Mestecky J, Huang W-Q, Anreddy SR, Lau K, Novak J. Elevated serum concentration of galactose-deficient IgA1 in pediatric patients with IgA nephropathy detected with Helix aspersa lectin. Kidney Int (under revision) McDonald RA, Smith JM, Ho M, Lindblad R, Grimm P, Wyatt R, Azar M, Liereman D. Bridges N, Harmon W. Increased post-transplant lymphoproliferative disease in pediatric renal transplant recipients enrolled in steroid withdrawal trial. Am J Transplant (submitted) |