| Publications :: | Associate
Professor of Pediatrics Division of Pediatric Critical Care 
Assistant Professor, Pediatrics and Obstetrics/Gynecology Dr. Talati’s
basic research interests focus on the role of inflammation in diseases
affecting primarily the newborn and premature infant. He has studied
the interaction of exogenous surfactant used for the treatment of
hyaline membrane disease with host defense mechanisms in infants.
In previous studies he has shown the suppressive effects of exogenous
surfactant on various inflammatory mediators produced by microorganisms
commonly affecting neonates. His current work includes the identification
of mechanisms responsible for macrophage activation by group B streptococci,
a common neonatal pathogen, in a mouse macrophage cell model. His
project focuses on 1) Different bacterial components and their roles
in macrophage activation, 2) Intracellular pathways of macrophage
activation in response to group B streptococci, 3) Bacterial killing
in the presence of various antibiotics and resulting effects on inflammatory
mediator production. His work has important implications for the treatment
of serious infections in the newborn. |
| Stovall,
SH, Yi, A-K, Meals, EA, Talati, AJ, Godambe, SA, and English BK. “Role
of vav1 and src-related tyrosine kinases in macrophage activation
by CpG DNA”. J Biol Chem. 2004 Apr 2; 279(14):13809-16. Epub
2004 Jan 28. Koneru P, Kaufman RA, Talati AJ, Jenkins MB, Korones SB: Successful treatment of sodium polystyrene sulfonate bezoars with serial water-soluble contrast enemas. Journal of Perinatology 23:431-433, 2003. Blackall DP, Liles LH, Talati A: In utero development of a warm-reactive autoanti-body in a severely jaundiced neonate. Transfusion 42:44-47, 2002. Talati AJ, Crouse DT, English BK, Newman C, Harrison L, Meals E: Immunomodulation by exogenous surfactant: effect on TNF-a secretion and luminol-enhanced chemilumi-nescence activity by murine macrophages stimulated with group B streptococci. Microbes and Infection 3:1-7, 2001. Talati AJ, Salim MA, Korones SB: Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn: A case report. American Journal of Perinatology 17(2): 69-71, 2000. Haddad B, Mercer B, Livingston JC, Talati A, Sibai BM: Outcome after successful resuscitation of babies born with Apgar scores of 0 at both one and five minutes. American Journal of Obstetrics and Gynecology 182:1210-4, 2000. Talati AJ, Crouse DT, English BK, Newman C, Livingston L, Meals E: Exogenous bovine surfactant suppresses TNF alpha release by murine macrophages stimulated by genital mycoplasmas. Journal of Infectious Diseases 178:1122-1125, 1998. |
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