| Publications :: | Professor of Pediatrics Division of Pediatric Nephrology 
Elevated blood pressure has a major impact upon the health of the heart and the kidneys. Children may have elevated blood pressure as a result of kidney disease or may have the beginning of adult high blood pressure in childhood. The exact level of blood pressure at which one can anticipate damage to kidneys and heart muscle is not as clearly defined in children as it has been in adults. This is important because it will guide treatment of children with elevated blood pressure. Dr. Deborah Jones’ research is aimed at early detection of vascular disease. Hypertension can induce changes in the thickness of the heart muscle and alterations in arterial thickness and stiffness. Measurement of 24-hour ambulatory blood pressure is the most reliable and consistent method for characterization of BP levels. Studies to date have demonstrated that stage 2 systolic hypertension and obesity are associated with left ventricular hypertrophy. Increased diastolic BP is associated with increased uric acid levels and eccentric left ventricular hypertrophy after controlling for degree of obesity. In addition to the effect of hypertension on left ventricular mass, the ratio of plasma aldosterone to renin is also associated with increased left ventricular mass independent of BP levels. Using non-invasive methods to characterize central aortic pulse wave and pressure, African-Americans have increased conduit artery stiffness as compared to Caucasians with hypertension. |
Jones DP, Richey PA, Alpert BS, Li R. Serum uric acid and ambulatory blood pressure in children with primary hypertension. Pediatr Res. 2008; 64(5):556-561 Richey PA, DiSessa TG, Somes GW, Alpert SC, Jones DP. Ambulatory blood pressure predicts increased left ventricular mass in children at risk for hypertension. J Pediatr. 2008; 152(3):343-348 Green D, Springate J, Spunt S, Jones DP. Renal late effects following treatment of childhood cancer. Pediatr Blood and Cancer, 2008; 51:724-731 Zepeda-Orozco D, Ault BH, Jones DP. Factors associated with acute renal failure in children with rhabdomyolysis-associated pigment nephropathy. Pediatric Nephrology 2008; 23(12):2281-2284 Jones DP, HN Noe. Renal Disease in Childhood. In Campbell-Walsh Urology, 9th edition, Wein AJ, Kavoussi LR, Novick AC, Partin AW, Peters CA (eds), Elsevier, Philadelphia, 2008 Richey PA, Somes GW, Alpert BS, Jones DP. Comparison of European and Task Force ambulatory blood pressure reference standards in a biracial cohort of children at risk for hypertension. Submitted to J Hypertension, 2008 Jones DP, Richey PA, Alpert BS: Validation of the AM5600 ambulatory blood pressure monitor in children and adolescents. Blood Pressure Monitoring, 2008; 13(6):349-351. Lau KK, Ault BH, Jones DP, Butani L: Induction therapy for pediatric focal proliferative lupus nephritis: cyclophosphamide versus mycophenolate mofetil. J Pediatr Health Care 2008; 22(5):282-288. Daw N, Gregornik D, Wilimas J, Marina N, Shearer P, Jenkins J, Shah A, Tan M, Rodman J, Jones DP: Renal function after ifosfamide, carboplatin, and etoposide (ICE), nephrectomy, and radiation in children with high risk Wilms tumor. European Journal of Cancer, 2009; 45(1):99-106 Jones DP. Hypertension. In Pediatric Nephrology for the Primary Care Physician, Barakat A, Chesney RW (eds) American Academy of Pediatrics, Elk Grove Village, 2009, pp 387-311 Li R, Richey PA, DiSessa TG, Alpert BS, Jones DP: Blood aldosterone to renin ratio, ambulatory blood pressure and left ventricular mass in children. J Pediatr 2009; 155(2):170-175 Collins RT, Barkoudah E, Jones DP, Somes GW, Alpert BS: Arterial stiffness in adolescents with chronic kidney disease or hypertension. Hypertension, 2009 (in press). Jones DP, Richey PA, Alpert BS: Comparison of ambulatory blood pressure reference standards in children evaluated for hypertension. Blood Pressure Monitoring, 2009; 14(3):103-107. |