| Publications :: | Professor
of Pediatrics Division Chief, Pediatric Infectious Diseases 
Dr. Keith English’s laboratory studies the biochemical pathways
that regulate the response of macrophages and monocytes to bacteria
and bacterial products. White blood cells, including blood monocytes
and tissue macrophages, constitute a critical part of the body’s
innate immune system. The innate immune system plays a critical role
in the response to primary infection with many types of pathogens.
While the production of inflammatory mediators such as tumor necrosis
factor (TNF) and nitric oxide (NO) plays an important role in the
control of many types of infectious agents, the overproduction or
unbalanced production of these host mediators may also damage the
body. In fact, overproduction of TNF, NO and other substances by monocytes
and macrophages appears to play a primary role in the development
of septic shock and other acute and chronic diseases characterized
by intense or prolonged inflammation. The long-term impact of these
studies on child health will be in the development of novel strategies
to prevent or treat serious infections as well as other disorders
characterized by severe or prolonged inflammation, including juvenile
rheumatoid arthritis, burn injury and inflammatory bowel disease.
In addition, these studies have important implications for the development
of antibiotic treatment strategies for serious infections in children. |
Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor. Am J Respir Cell Mol Biol 2005; 33:394-401 English BK, Buckingham SC. Impact of antimicrobial resistance on therapy of bacterial pneumonia in children. Adv Exp Med Biol 2006; 582:125-135 Hardin AO, Meals EA, Yi T, Knapp KM, English BK. SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages. Biochem Biophys Res Comm 2006; 342:547-555 Gaur AH, English BK. The judicious use of antibiotics: an investment towards optimized health care. Indian J Pediatr 2006; 73:343-350 Buckingham SC, McCullers JA, Luján-Zilbermann J, Knapp KM, Orman KL, English BK. Early vancomycin therapy and adverse outcomes in children with pneumococcal meningitis. Pediatrics 2006; 117:1688-1694 English BK, Maryniw EM, Talati AJ, Meals EA. Diminished macrophage inflammatory response to Staphylococcus aureus isolates exposed to daptomycin versus vancomycin or oxacillin, Antimicrob Agents Chemother 2006; 50: 2225-2227 |