| Publications :: | Le
Bonheur Professor and Chair UTHSC, Dept. of Pediatrics 
Dr. Russell Chesney has been active in the Children's Foundation Research
Center since its inception and has served both on the scientific advisory
committee and on the affiliation committee between the University
of Tennessee and the Children's Foundation of Memphis. Dr. Chesney has studied amino acid transport by the kidney for more than 30 years. He has been interested in factors that regulate the renal handling of the amino acid taurine. Working with Dr. Xiaobin Han, they cloned the gene for the rat taurine transporter and demonstrated that its expression can be regulated by a variety of mechanisms including dietary exposure as well as a variety of transcriptional factors. Dr. Chesney's work has focused on factors regulating taurine transport and their relationship to cell volume regulation as a means of protecting against renal damage in cell death. In the future Dr. Chesney will collaborate with Dr. Xiaobin Han to create cell lines and lines of genetically altered mice to test the influence of alterations in the expression of the taurine transporter by the chemotherapeutic agent cisplatin. It is anticipated that these studies will help define the role of taurine in protection against renal damage and to better understand the nature of the renal and cell volume regulation of the taurine transporter gene in both disease and health. |
Han X, Chesney RW. Regulation of taurine transporter gene (TauT) by cisplatin. Pediatr Nephrol 2005; 20(8):1067-1072 Han X, Patters AB, Jones DP, Zelikovic I, Chesney RW. The taurine transporter: mechanisms of regulation. Acta Physiol 2006; 187:61-73 Han X, Chesney RW. Is TauT an anti-apoptotic gene in renal cells? Adv Exp Med Biol 2006; 583:59-68 Han X, Chesney RW. Mechanisms of regulation of TauT expression – a complex interplay of regulatory systems. Adv Exp Med Biol 2006; 583:79-90. Xu L, Han X, Chesney RW, Birrer M. Regulation of TauT by c-jun oncogene. J Biol Chem 2006 (under revision) |
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