| Publications :: | Plough
Foundation Professor of Pediatrics Division of Pediatric Cardiology Director, UTHSC General Clinical Research Center  In
1981 Dr. Bruce Alpert made the observation that the exercise blood
pressure (BP) in a group of African-American children aged 6-15 was
higher than the BP obtained in a similar group of white children.
The same difference in stress-related BP was noted in response to
a video game played under laboratory conditions. At UTHSC Dr. Alpert
confirmed this differential BP response to several stressors in both
urban and rural African-Americans. The next step in the investigation
of the markers and mechanisms of the evolution of hypertension in
African-Americans was to demonstrate that heightened peripheral vascular
resistance explained the higher BP. In his current NIH grant, “Genetics
of Cardiovascular Reactivity in Black Youth,” Dr. Alpert, Dr.
Robert Kelsey, and their co-investigators, including Dr. Michael Quasney,
are studying the relationship(s) among measures of BP reactivity to
four different laboratory stressors and polymorphisms (SNPs) in over
40 genes that are involved with the production of vasoconstriction,
leading to elevated BP. These results will lead to new interventions
to prevent and treat hypertension in African-American children and
adults. |
| Alpert
BS: Exercise as a therapy to control hypertension in children.
Int J Sports Med, 21 Supplement 2:S94-97, 2000. Kelsey RM, Patterson SM, Barnard M, Alpert BS: Consistency of hemodynamic responses to cold stress in adolescents. Hypertension, 36:1013-1017, 2000. Salim MA and Alpert BS: Sports and Marfan Syndrome: Awareness and early diagnosis can prevent sudden death. The Physician and Sport Medicine, 29:80, 2001. Ornduff S, Kelsey RM, Bursi C, Alpert BS, Bada HS: Child abuse potential in at-risk African-American mothers: The role of life-experience variables. American Journal of Orthopsychiatry, 72:433-444, 2002. Harshfield GA, Wilson ME, Treiber FA, and Alpert BS: A comparison of ambulatory blood pressure patterns across populations. Blood Press Monitor, 7:265-269, 2002. Herman MI, Alpert BS: Coarctation of the aorta and cerebellar infarction: A case report. Pediatric Emergency Care Journal, in press. Turner JR and Alpert BS: The 6 Step healthy heart program. Published by Xlibris Corp., 2003. Alpert BS, Hasselle M, Ornduff S: (Book Chapter) Non-Pharmacologic treatment of hypertension in children. Pediatric Hypertension, (Humana Press, Inc, Totowa, NJ), in press |
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